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Sung I. Koo, PhD

Professor and Department Head

Phone: 860-486-3495
Fax: 860-486-3674
Email: sung.koo@uconn.edu

Education

  • B.S. in Animal Science: Kon-Kuk University, Seoul, Korea, February 1970. Korea University College of Arts and Sciences, Seoul, Korea, 1964-1965.
  • M.S. in Animal Nutrition: University of New Hampshire, Durham, NH, June 1973.
  • Ph.D. in Nutrition (Nutritional Biochemistry): Clemson University, Clemson, SC, May 1976.
  • Postdoctoral training in nutritional biochemistry and gastrointestinal physiology: Cornell University School of Veterinary Medicine, Ithaca, NY, (Mentor: Robert Wasserman, Ph.D., Professor), June 1976 - May 1978.

Professional Appointments

  • Professor and Head: 2002 - present, Department of Nutritional Sciences, University of Connecticut, Storrs, CT.
  • Professor and graduate faculty: 1990 - 2002, Department of Human Nutrition, Kansas State University, Manhattan, KS.
  • Adjunct Graduate Faculty: 1991 - 2002, Department of Anatomy and Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS.
  • Professor: 1989 - 1990, Department of Biochemistry, Oral Roberts University School of Medicine, Tulsa, OK.
  • Associate Professor: 1984 - 1989, Department of Biochemistry, Oral Roberts University School of Medicine, Tulsa, OK.
  • Assistant Professor: 1979 - 1984, Department of Biochemistry, Oral Roberts University School of Medicine, Tulsa, OK.
  • Research Associate: 1976 - 1978, Department of Physiology, Cornell University School of Veterinary Medicine, Ithaca, NY.

Administrative Appointments

  • Department Head, Department of Nutritional Sciences, University of Connecticut, 2002-present
  • Assistant Department Head, Department of Human Nutrition, Kansas State University, 1999-2002.
  • Graduate Program Coordinator, Department of Human Nutrition, Kansas State University, 1998-2002.
  • Human Nutrition Panel Manager, USDA National Research Initiative Competitive Grants Programs 1999-2001.
  • Nutrition Coordinator with Dietetics, Kansas State University, 1997.
  • Human Nutrition Coordinator, Oral Roberts University School of Medicine, 1985-1990.

Professional Society Memberships

  • American Society for Nutrition (ASN)

Editorial Boards

  • Journal of Nutrition, 2002 - present.
  • Journal of Nutritional Biochemistry, 2001 - present.
  • American Journal of Physiology: Gastrointestinal & Liver Physiology, 2003 - present.
  • Journal of Food Science and Nutrition, 1998 - 02.
  • Nutraceuticals and Food, 2002 - 03.

Review Panels & Advisory Boards

  • USDA Higher Education Multicultural Scholars Program Review Panel 2007
  • Florida State University Department of Nutrition, Food & Exercise Sciences External Advisory Board, 2006-2008.
  • NIH NationalCenter for Complementary and Alternative Medicine Panel, 2004.
  • University of Kentucky Superfund Program External Advisory Board, 2003-2006.
  • University of Kentucky Tobacco & Health Research Institute, 2002.
  • USDA NRI Competitive Grants Program Human Nutrition Panel Manager, 1999-2001.
  • USDA Initiative for Future Agriculture and Food System (IFAFS) Functional Foods Panel, 2001.
  • USDA Multidisciplinary Graduate Education and Traineeship Program, 2001.
  • NIH National Center for Complementary and Alternative Medicine Panel, 1999-2001.
  • US Department of Veterans Affairs Merit Review, 2001.
  • Philip Morris External Research Program, 2000-2003.
  • NIH NCCAM Special Emphasis Panel on Botanical Research Centers, 2000.
  • Auburn University Biogrant Program, 2000.
  • USDA NRI Competitive Grants Program Human Nutrition Panel, 1997-1999.
  • The City University of New York (CUNY) Grant Program, 1997.
  • American Heart Association Kansas Affiliate Peer Review Committee, 1994-1997.
  • American Heart Association Kansas Affiliate Research Committee, 1994-1997.
  • USDA NRI Competitive Grants Program Human Nutrition Ad Hoc Reviewer, 1994-1996.
  • USDA ARS Research Project Merit Review, 1994.
  • NIH National Center for Nursing, Nursing and Biology Interface Program, Study Section, 1992.
  • Natural Sciences and Engineering Research Council of Canada Research Grants, 1992.

Awards and Honors

  • Faculty Research Excellence Award: College of Human Ecology, KSU, 1994.
  • Faculty Research Excellence Award: College of Human Ecology, KSU, 2002.
  • New Investigator Award: National Institute of Health (NIH) 1983-1986.

Courses taught

  • Advanced Macronutrient Metabolism (graduate), 1998 - 2002
  • Nutrient Metabolism (undergraduate): 1995 - 2002
  • Advanced Nutrition: Proteins and Amino Acids (graduate): 1990 - 1998
  • Advanced Nutrition: Carbohydrates and Lipids (graduate): 1991 - 1998
  • Nutritional Biochemistry (Bionutrition: graduate): 1991 - 1995
  • Advanced Nutrition: Fat-Soluble Vitamins (graduate): 1991
  • Biochemical Techniques: 1979 - 90
  • Medical Biochemistry: 1979 - 90
  • Medical Human Nutrition: 1981 - 89
  • Medical Nutrition Elective: 1981 - 83
  • Undergraduate Biochemistry (Course Director): 1981 - 85
  • Amino Acid Biochemistry: 1981 - 83

Graduate Students Supervised

  • Wei Zou, PhD, 1997 - 2002; Carnitine and fatty acid metabolism; Major advisor.
  • Shu Wang, PhD, 2000 - 2002; Green tea catechins and phospholipase A2; Major advisor
  • Jody Stotts, MS, 2000 - 2002; Green tea, history, and manufacturing practices; Major advisor
  • Lene Loest, MS, 1999 - 2001; Green tea and cholesterol absorption; Major advisor.
  • Rob Musser, PhD, 1996 - 2000; Carnitine and in-utero fetal development in swine; Member of Thesis Committee.
  • Margaret Jiang, MS, 1998 - 2000; Egg phospholipid and cholesterol absorption; Major advisor.
  • Sang-kyu Noh, PhD, 1996 - 2000; Biochemical defects in lipid absorption in zinc deficient rats; Major advisor.
  • Pat O'Quinn, PhD, 1996 - 1999; Conjugated linoleic acids, vitamin E, and lean body mass in swine; Member of Thesis Committee.
  • Richard Greenwood, PhD, 1996 - 1999; Carnitine and protein metabolism in swine; Member of Thesis Committee.
  • Jim Smith, PhD, 1996 - 1998; Optimal dietary levels of selected amino acids in growing and adult pigs.; Member of Thesis Committee.
  • Clint Löest, PhD, 1995 - 1998 ; Choline metabolism in the ruminant.;Member of Thesis Committee.
  • Khalid Amurshed, PhD, 1994 - 1998; Nutritional determinants of muscular hypertrophy; Member of Dissertation Committee.
  • Sang-kyu Noh, MS, 1994 - 1996; Effects of estradiol on fatty acid metabolism.; Major advisor.
  • James Smith, MS, 1994 - 1996; Effects of betaine, carnitine, and chromium on the growth and composition of growing and finishing pigs. Member of Thesis Committee.
  • Ling Yang, MS, 1993 - 1995; Effects of estradiol on chylomicron metabolism. Major advisor.
  • Bret Healy, PhD, 1993 - 1995; Effects of anabolic compounds on protein/amino acid utilization in cattle. Member of Dissertation Committee.
  • Jennifer Lee, MS, 1993 - 1995; Effects of nutrition and exercise on maternal weight gain. Member of Thesis Committee.
  • Brian Richert, PhD, 1992 - 1995; Branched chain amino acid requirement in lactating sows. Member of Dissertation Committee.
  • Kevin Owen, PhD, 1992 - 1995; Effects of carnitine on branched chain amino acid metabolism in growing pigs. Member of Dissertation Committee.
  • Yilfashewa Shiferaw, PhD, 1992 - 1995; Study on factors affecting storage quality of hard white winter wheat. Graduate School Chair for Dissertation Examination and Presentation.
  • Philomina Gwanfogbe, PhD, 1991 - 1994; Relationship between cultural factors and maternal and infant nutrition in rural Cameroon. Member of Dissertation Committee.
  • Staci Brandyberry, MS, 1992 - 1994; Fat deposition in women over the life span. Member of MS Report Supervisory Committee.
  • Joung J. Ahn, PhD, 1991 - 1994; The role of phosphatidylcholine in the intestinal absorption of retinol and fatty acids in zinc deficient rats. Major advisor.
  • Kim Friesen, PhD, 1991 - 1994; Influence of dietary lysine on growth and carcass composition of high-lean growth gilts. Member of Dissertation Committee.
  • Rajesh Mehta, PhD. 1990 - 1993; Antioxidative effects of natural antioxidants found in selected foods. Member of Dissertation Committee.
  • Steven J. Dodds, MD and PhD, 1990; Neuroregulation of food intake in amino acid deficiencies. Member of Dissertation Committee.
  • Helen S. Wang, MS, 1990 - 1992; Metabolism of stearic acid. Major advisor
  • Gary E. Fitzner, PhD, 1990 - 1992; Effects of daily pocine somatotropin administration on the lysine requirement of growing pigs. Member of Dissertation Committee.
  • Eldon A. Smith, PhD, 1991; Polyacrylamide environmental biodegradation and potential neurotoxicity. Graduate School Chair for Dissertation Examination and Presentation.
  • Yvonne Goetsch, MD, 1987. Summer Scholarship Research: Hepatocellular lipid distribution in copper-deficient Rats. Major advisor
  • Jasmine Chow, MD, 1985. Summer Scholarship Research: Effect of marginal zinc deficiency on intestinal cholesterol esterase activity. Major advisor.
  • Edward Geno, MS, 1984; Maternal ingestion of dietary cholesterol on the mineral status of the dam and the offsprings. Major advisor.
  • Daniel Tan, MS, 1984; Glycogen loss patterns in rat adductor muscles during low-intensity exercise. Member of Thesis Supervisory Committee.

Postdoctoral Trainees

  • Sang K. Noh, PhD, Research Associate: 2000 - present.; Research area: Zinc nutrition and intestinal absorption of fat-soluble vitamins.
  • Patrick O'Quinn, PhD, Research Associate: 1999; Research area: Conjugated linoleic acids and fat partitioning.
  • Tom Sun, PhD, Instructor: 1998-1999; Research area: Green tea polyphenols and cholesterol absorption
  • Christine C. Lee, Research Associate: 1985 - 89; Research Area: Lipoprotein metabolism and biochemistry in zinc and copper deficiencies.

Research

  • Mechanisms of intestinal absorption of lipids and lipid-soluble vitamins
  • Dietary phytochemicals and lipid metabolism

Grants

  • NIH National Center for Complementary and Alternative Medicine, Hypocholesterolemic action of green tea extracts Principal Investigator; April 1, 2004-March 31, 2006
  • Lonza Inc. A clinical study on the effect of L-carnitine on the loss of fat during weight reduction; Principal Investigator with Dr. Maria Luz Fernandez, CoPI ; Sept 1, 2002 - Aug 31, 2004.
  • Lonza Inc. Dietary L-carnitine supplement: Its effect on fat-soluble vitamin status in an aging female rat model.; September 1, 2002 - August 31, 2004.
  • USDA - NRI Competitive Research Grants Program, Role of vitamin A in lung epithelial cell repair. Co-Investigator with Richard Baybutt, PI, KSU; Sept 1, 1999 - Aug 31, 2002.
  • American Heart Association Heartland Affiliate; Synthesis and biological evaluation of cholesteryl ester transfer protein inhibitors: chloropuupehenone and its analogs; Co-Principal Investigator with Duy Hua, Department of Chemistry, KSU); July 1, 2000 - June 30, 2002.
  • USDA- NRI Competitive Research Grants Program, Zinc deficiency: Its effect on vitamin A transport; Principal Investigator; September 1, 1996 - August 31, 2001.
  • Hill's Science and Technology Center; The Role of carnitine in fatty acid metabolism; Principal Investigator, ; July 1, 1997 - June 30, 2001.
  • Lonza Inc.; Effects of modified tall oil on body composition in rats when fed in conjunction with other nutritional supplements; Principal Investigator; ; Oct 22, 1999 - April 21, 2000.
  • AMPC (Proliant), Inc.; The effect of a bovine plasma IgG fraction on lymphatic absorption of cholesterol in a rat model; Principal Investigator; September 1, 1998 - December 31, 2002.
  • The American Heart Association, Kansas Affiliate; Estrogen replacement: Its effect on intestinal fat absorption, Principal Investigator; August 1, 1995 - July 31, 1997.
  • The American Heart Association, Kansas Affiliate; Effect of estrogen replacement and dietary copper on cholesterol metabolism in ovariectomized rats; Principal Investigator August 1, 1991 - December 31, 1994.
  • USDA- NRI Competitive Research Grants Program; Zinc deficiency: Its effect on vitamin A transport; Principal Investigator September 1, 1990 - August 31, 1993.
  • The National Live Stock and Meat Board; In-vivo clearance of chylomicrons enriched with stearic acid; Principal Investigator; June 1, 1991 - December 31, 1992.
  • NIH, National Heart, Lung and Blood Institute Grant (RO1); Cholesterol transport: Effect of zinc and copper nutrition; Principal Investigator July 1, 1986 - June 30, 1989.
  • National Institutes of Health (NIH) New Investigator Award (R29) Zinc nutrition and intestinal absorption of cholesterol; Principal Investigator; January 1, 1983 - June 30, 1986.

Publications

  • Pasiakos, S.M., Mettel, J.B., West, K., Lofgren, I.E., Fernandez, M.L., Koo, S.I. and Rodriguez, N.R. Maintenance of resting energy expenditure after weight loss in premenopausal women: potential benefits of high protein and reduced-calorie diet. Metabolism 57: 458-464, 2008.
  • Shrestha, S., Ehlers, S.J., Lee, J-Y., Fernandez, M-L, and Koo, S.I. Dietary green tea extract lowers plasma and hepatic triglyceride and decreases the expression of SREBP-1c mRNA and its responsive genes in fructose-fed ovariectomized rats. J. Nutr. (Submitted), 2008.
  • Hooshmand S, Balakrishnan A, Clark RM, Owen KQ, Koo SI, and Arjmandi BH. Dietary L-carnitine supplementation improves bone mineral density by suppressing bone turnover in aged ovariectomized rats. Phytomedicine 15:595-601, 2008.
  • Bruno, R.S., Dugan, C.E., Smyth, J.A., DiNatale, D.A., and Koo, S.I. Green tea extract protects against hepatic steatosis and injury in leptin deficient, spontaneously obese mice. J. Nutr. 138:323-331, 2008.
  • Woodworth, J.C., Tokach, M.D., Nelssen, J.L., Goodband, R.D., Dritz, S.S., Koo, S.I., Minton. J.E., and Owen K.Q. Influence of dietary L-carnitine and chromium picolinate on blood hormones and metabolites of gestating sows fed one meal per day. J Anim Sci. 85:2524-37, 2007.
  • Clark, R.M., Balakrishnan, A., Waters, D., Aggarwal D., Owen, K.Q., Koo, S.I. L-Carnitine increases liver α-tocopherol and lowers liver and plasma triglycerides in aging ovariectomized rats. J. Nutr. Biochem. 18: 623-628, 2007.
  • Hennig, B., Ettinger, A., Jandacek, R.J., Koo, S.I., McClain, C., Seifried, H., Silverstone, A., Watkins, B., and Suk, W.A. Using nutrition for intervention and prevention against environmental chemical toxicity and associated diseases. Environ. Health. Perspect. 493-495, 2007.
  • Koo, S.I. and Noh, S.K. Green tea as inhibitor of the intestinal absorption of lipids: Potential mechanism for its lipid-lowering effect. J. Nutr. Biochem. 18:179-183, 2007.
  • Wang, S., Noh, S.K. and Koo, S.I. Epigallocatechin gallate and caffeine differentially inhibit the intestinal absorption of cholesterol and fat in ovariectomized rats. J. Nutr. 136: 2791-2796, 2006.
  • Wang, S., Noh, S.K. and Koo, S.I. Green tea catechins inhibit pancreatic phospholipase A2 and intestinal absorption of lipids in ovariectomized rats. J. Nutr. Biochem. 17: 492-498, 2006.
  • Lofgren, I., Zern, T., Herron, K., West, K.L., Sharman, J.,Volek, J.F., Shachter, N.S., Koo, S.I. and Fernandez, M-L. Weight loss reduces the atherogenicity of LDL in premenopausal women. Metabolism, 54:1133-1141, 2005.
  • Zou, W., Noh, S.K., Owen, K.Q. and Koo, S.I. Dietary L-carnitine enhances the lymphatic absorption of fat and a-tocopherol in ovariectomized rats. J. Nutr. 135: 753-756, 2005.
  • Patalay, M., Lofgren, I.E., Freake, H., Koo, S.I. and Fernandez, M-L. The lowering of plasma lipids following a weight reduction program is related to increased expression of the LDL receptor and lipoprotein lipase. J. Nutr. 135: 735-739, 2005.
  • Lofgren, I., Herron, K.,West, K., Zern, T., Patalay, M., Koo, S.I. and Fernandez, M-L. Relationships of carbohydrate intake and coronary disease biomarkers in a population of overweight premenopausal women. J. Nutr. Biochem. 16: 245-250, 2005.
  • Noh, S.K. and Koo, S.I. Milk sphingomyelin is more effective than egg sphingomyelin in inhibiting intestinal absorption of cholesterol and fat in rats. J. Nutr. 134:2611-2616, 2004.
  • Duy, H.H., Huang, X., Chen, Y., Battina, S.K., Tamura, M., Noh, S.K., Koo, S.I., Namatame, I. and Tomoda, H. Total Syntheses of (+)-Chloropuupehenone, (+)-Chloropuupehenol, And Their Analogs, And Evaluation of Bioactivities. J. Organic Chem. 69: 6065-6078, 2004.
  • Lofgren, I., Herron, K., Zern, T., West, K., Patalay, M., Schachter, N.S., Koo, S.I. and Fernandez, M.L. Waist circumference is a better predictor than body mass index for coronary heart disease risk in overweight premenopausal women. J. Nutr. 134: 1071-1076, 2004.
  • Woodworth, J.C., Minton, J.E., Tokach, M.D., Nelssen, J.L., Goodband, R.D., Dritz, S.S., Koo, S.I. and Owen K.Q. Dietary L-carnitine increases plasma leptin concentrations of gestating sows fed one meal per day. Domestic Anim. Endocrinol. 26: 1-9, 2004.
  • Noh, S.K. and Koo, S.I. Egg sphingomyelin lowers the lymphatic absorption of cholesterol and a-tocopherol in rats. J. Nutr. 133: 3571-3576, 2003.
  • Noh, S.K. and Koo, S.I. Low zinc intake decreases the lymphatic output of retinol in rats infused intraduodenally with beta-carotene. J. Nutr. Bioch. 14: 147-153, 2003.
  • Noh, S.K., Koo, S.I. and Y. Jiang. (+)-Catechin is a potent inhibitor of intestinal absorption of cholesterol in rats. Nutraceuticals & Food, 8: 1-6, 2003.
  • O'Quinn, P.R., Koo, S.I., Noh, S.K., Nelssen, J.L., Goodband, R.D. and Tokach, M.D. Effects of modified tall oil on body composition and serum and tissue levels of cholesterol, phospholipids, and alpha-tocopherol in adult ovariectomized rats. Nutr. Res. 23: 549-566, 2003.
  • Löest, L., Noh, S.K., and Koo, S.I. Green tea extract lowers the lymphatic absorption of cholesterol and alpha-tocopherol in ovariectomized rats. J. Nutr. 132:1282-1288, 2002.
  • Waylan, A.T., O'Quinn, P., Unruh, J.A., Nelssen, J.L., Goodband, R.D., Woodworth, J.C., Tokach, M.D., and Koo, S.I. Effects of modified tall oil and vitamin E on growth performance, carcass characteristics, and meat quality of growing-finishing pigs. J. Anim. Sci. 80:1575-1585, 2002.
  • Koo, S.I. and Noh, S.K. Phosphatidylcholine inhibits and lysophosphatidylcholine enhances the lymphatic absorption of alpha-tocopherol in adult rats. J. Nutr. 131:717-722, 2001.
  • Jiang, Y., Noh, S.K., and Koo, S.I. Egg phosphatidylcholine decreases the lymphatic absorption of cholesterol in rats. J. Nutr. 131:2358-2363, 2001.
  • Noh, S.K. and Koo, S.I. Intraduodenal infusion of lysophosphatidylcholine restores the lymphatic absorption of vitamins A and E in rats fed a low zinc diet. Soc. Exp. Biol. Med. 226:342-348, 2001.
  • Noh, S.K. and Koo, S.I. Enteral infusion of phosphatidylcholine increases the lymphatic absorption of fat, but lowers the absorption of alpha-tocopherol in rats fed a low zinc diet. J. Nutr. Biochem. 12: 330-337, 2001.
  • Noh, S.K. and Koo, S.I. Feeding of a low zinc diet lowers the tissue concentrations of alpha-tocopherol in adult rats. Biol. Trace Elem. Res. 81:153-168, 2001.
  • Owen, K.Q., Ji, H., Maxwell, C.V., Nelssen, J.L., Goodband, R.D., Tokach, M.D., Tremblay, G.C., and Koo, S.I. Dietary L-carnitine suppresses mitochondrial branched-chain keto acid dehydrogenase activity and enhances protein accretion and carcass characteristics of swine. J. Anim. Sci.79:3104-3112, 2001.
  • Koo, S.I., Noh, S.K, Löest, H.B., and Wang, S. Green tea and its catechins as a dietary or pharmacologic means of lowering cholesterol absorption. Proc. Intl. Sym. Fd. Nutr. & Hlth for 21st Century. Korean Soc. Food Sci. Nutr. 74-89, 2001.
  • Noh, S.K., Koo, S.I., and Jeon, I.J. Estradiol replacement in ovariectomized rats increases the hepatic concentration and biliary secretion of a-tocopherol and polyunsaturated fatty acids. J. Nutr. Biochem. 10:110-117, 1999.
  • Kim, E.S., Noh, S.K., and Koo, S.I. Marginal zinc deficiency lowers the lymphatic absorption of a-tocopherol in rats. J. Nutr. 128:265-70, 1998.
  • Chung, H.J. and Koo, S.I. Estradiol replacement elevates the serum and tissue levels of a-tocopherol in ovariectomized rats. J. Nutr. Biochem. 9:67-74, 1998.
  • Yang, L. and Koo, S.I. Estradiol replacement and dietary copper in ovariectomized rats additively increase the serum levels of HDL-cholesterol and body status of copper. J. Trace Elements Exp. Med. 11:45-58, 1998.
  • Noh, S.K. and Koo, S.I. The lymphatic absorption of lipids is normalized by enteral phosphatidylcholine infusion in ovariectomized rats with estrogen replacement. J. Nutr. Biochem. 8:152-161, 1997.Yang, L. and Koo, S.I. Estradiol replacement lowers the lymphatic absorption of fatty acids and output of phospholipid. J. Nutr. Biochem. 7:214-221, 1996.
  • Ahn, J. and Koo, S.I. Effects of zinc and essential fatty acid deficiencies on the lymphatic absorption of vitamin A and secretion of phospholipids. J. Nutr. Biochem. 6:595-603, 1995.
  • Ahn, J. and Koo, S.I. Intraduodenal infusion of phosphatidylcholine restores the lymphatic absorption of vitamin A and oleic acid. J. Nutr. Biochem. 6:604-612, 1995.
  • Ahn, J. and Koo, S.I. Effect of zinc deficiency on the intestinal absorption, plasma clearance, and urinary excretion of 3H-vitamin A in rats. J. Trace Elements Exp. Med. 7:153-166, 1995.
  • Wang, S. and Koo, S.I. Plasma clearance and hepatic utilization of stearic, myristic, and linoleic acids introduced via chylomicrons in rats. Lipids 28:697-703, 1993.
  • Wang, S. and Koo, S.I. Evidence for distinct metabolic utilization of stearic acid in comparison with palmitic and oleic acids. J. Nutr. Biochem. 4:594-601, 1993.
  • Koo, S.I., Lee, C.C. and Sabin, L. The effect of copper deficiency on the hepatic synthesis and release of cholesterol. J. Nutr. Biochem. 4:162-167, 1993.
  • Koo, S.I., Lee, C.C., Scott, R.L. and Stone, W.L. Plasma clearance of human 125I-low density lipoproteins (LDL) in copper-deficient rats. J. Nutr. Biochem. 3:45-51, 1992.
  • Brenner, G.M. and Koo, S.I. Effect of different dosages of estradiol on copper and zinc status, and high density lipoproteins in ovariectomized rats. J. Trace Elements Exp. Med. 3:55-65, 1990.
  • Koo, S.I. and Lee, C.C. Effect of marginal zinc deficiency on endothelial lipoprotein lipase activities in postheparin plasma, skeletal muscle and adipose tissues. Lipids 24:132-136, 1989.
  • Koo, S.I. and Lee, C.C. Distribution of cholesterol and apolipoproteins in plasma high-density lipoprotein subclasses from marginally zinc-deficient rats. Am. J. Clin. Nutr. 50:73-79, 1989.
  • May, H.E. and Koo, S.I. The reversed-phase HPLC behavior of retinyl esters. J. Liquid Chromatography 12:1261-1280, 1989.
  • Lee, C.C. and Koo, S.I. Effect of copper deficiency on the composition of three high-density lipoprotein subclasses as separated by heparin-affinity chromatography. Biochim. Biophys. Acta 963:278-287, 1988.
  • Brenner, G.M. and Koo, S.I. Estradiol-induced increase in serum high-density lipoprotein cholesterol and its relationship with zinc and copper status in ovariectomized rats. Horm. Metabol. Res. 20:597-599, 1988.
  • Koo, S.I., Lee, C.C. and Norvell, J.E. Effect of copper deficiency on the lymphatic absorption of cholesterol, plasma chylomicron clearance, and postheparin lipase activities. Proc. Soc. Exp. Biol. Med. 118:410-419, 1988.
  • Lee, C.C. and Koo, S.I. Separation of three compositionally-distinct subclasses of rat high density lipoproteins by heparin-affinity chromatography. Atherosclerosis 70:205-215, 1988.
  • Carter, J.W. and Koo, S.I. Evaluation of the polychlorobiphenyl Aroclor 1254 in an animal model of atherosclerosis. Arch. Environ. Contamin. Toxicol. 17:307-312, 1988.
  • Koo, S.I. and Lee, C.C. Compositional changes in plasma high density lipoprotein particles from marginally zinc-deficient male rats. Am. J. Clin. Nutr. 47:120-127, 1988.
  • Koo, S.I., Lee, C.C. and Norvell, J.E. Effect of marginal zinc deficiency on the apolipoprotein-B content and size of mesenteric lymph chylomicrons in adult rats. Lipids 22:1035-1040, 1987.
  • Koo, S.I., Norvell, J.E., Algilani, K. and Chow, J. Effect of marginal zinc deficiency on the lymphatic absorption of 14C-cholesterol. J. Nutr. 116:2363-2371, 1986.
  • Koo, S.I., Dodds, S.J. and Mercer, L.P. Optimization of the dietary level of histidine in relation to the serum concentration of zinc and copper in weanling rats. Nutr. Res. 6:967-979, 1986.
  • Koo, S.I., Algilani, K., Norvell, J.E. and Henderson, D.A. Delayed plasma clearance and hepatic uptake of lymph chylomicron 14C-cholesterol in marginrally zinc-deficient rats. Am. J. Clin. Nutr. 43:429-437, 1986.
  • Koo, S.I., Henderson, D.A., Algilani, K. and Norvell, J.E. Effect of marginal zinc deficiency on the morphological characteristics of intestinal nascent chylomicrons and distribution of soluble apoproteins of lymph chylomicrons. Am. J. Clin. Nutr. 42:671-680, 1985.
  • Koo, S.I. and Ramlet, J.S. Effect of dietary linoleic acid on the tissue levels of zinc and copper, and serum high-density lipoprotein cholesterol. Atherosclerosis 50:123-132, 1984.
  • Carter, J.W. and Koo, S.I. Effects of dietary Aroclor (PCBs) on serum levels of lipoprotein cholesterol and tissue distribution of zinc, copper and calcium in Fischer rats. Nutr. Rep. Int. 29:223-232, 1984.
  • Koo, S.I. and Winslow, S.L. A selective elevation in low-density lipoprotein cholesterol by 5 ppm of dietary cadmium. Nutr. Rep. Int. 27:131-136, 1983.
  • Koo, S.I. and Ramlet, J.S. Dietary cholesterol decreases the serum level of zinc: Further evidence for the positive relationship between serum zinc and high-density lipoproteins. Am. J. Clin. Nutr. 37:918-923, 1983.
  • Koo, S.I. and Williams, D.A. Relationship between the nutritional status of zinc and cholesterol concentration of serum lipoproteins in adult male rats. Am. J. Clin. Nutr. 34:2376-2381, 1981.
  • Koo, S.I. and Stanton, P. Effects of cellulose, pectin and guar gum on the distribution of serum cholesterol among lipoprotein fractions. Nutr. Rep. Int. 24:395-401, 1981.
  • Koo, S.I., Fullmer, C.S. and Wasserman, R.H. Effect of cholecalciferol and 1,25-dihydoxycholecalciferol on the intestinal absorption of zinc. J. Nutr. 110:1813-1818. 1980.
  • Koo, S.I., Currin, T.A., Johnson, M.G., King, E.W. and Turk, D.E. The nutritional value and microbial content of Musca Autumnalis. Poul. Sci. 59:2514-2518, 1980.
  • Koo, S.I., Fullmer, C.S. and Wasserman, R.H. Intestinal absorption and retention of 109Cd: Effect of cholecalciferol, calcium status and other variables. J. Nutr. 108:1812-1822, 1980.
  • Koo, S.I. and Turk, D.E. Effect of zinc deficiency on the intestinal transport of triglyceride in the rat. J. Nutr. 107:909-919, 1977.
  • Koo, S.I. and Turk, D.E. Effect of zinc deficiency on the ultrastructure of the pancreatic acinar cell and intestinal epithelium in the rat. J. Nutr. 107:896-908, 1977.

Abstracts

  • Shrestha, S., Odom, D., McGrane, M., Fernandez, M-L., and Koo, S.I. Dietary green tea extract (GT) lowers plasma triglyceride (TG) and the abundance of liver and intestinal microsomal TG transfer protein (MTP) mRNA in fructose-fed ovariectomized (OX) rats. FASEB J. (submitted), 2006.
  • Lofgren, I., Herron K.L., West, K.L., Zern, T.L., Brownbill, R., Ilich J, Koo, S.I. and Fernandez, M.L. A Weight loss program favorably modifies anthropometrics and reverses the metabolic syndrome and insulin resistance in premenopausal Women. FASEB J. #593.14, 2005.
  • Noh, S.K. and Koo, S.I. Luminal infusion of phytic acid lowers the lymphatic absorption of cholesterol (CH) and a-tocopherol (aTP) in rats. FASEB J. #576.5, 2004.
  • Patalay, M., Lofgren, I., Freake, H.C., Koo, S.I. and Fernandez, M.L. The lowering of plasma lipids following a weight reduction program are related to increased expression of the LDL receptor and lipoprotein lipase (LPL) in isolated mononuclear cells. FASEB J. #577.19, 2004.
  • Lofgren, I., Herron, K., Patalay, M., West, K., Zern, K., Brownbill, R., Ilich-Ernst, J., Koo, S.I. and Fernandez. Identifying risk factors for chronic disease in overweight premenopausal women. FASEB J. #117.2, 2004.
  • Zern, T.L., Lofgren, I., Herron, K., West, K.L., Patalay, M., Sharma M., Volek, J.S., Koo, S.I. and Fernandez, M.L. Weight loss intervention results in less atherogenic LDL particles in premenopausal women. FASEB J. #578.3, 2004.
  • Mettel, J.B., West, K.L., Lofgren, I.E., Fernandez, M.L., Koo, S.I. and Rodriguez, N.R. Effects of a weight loss intervention program on substrate oxidation in pre-menopausal women. FASEB J. #123.4, 2004.
  • Koo, S.I. Marginal zinc deficiency decreases intestinal retinol and beta-carotene absorption. Is the decrease attributable to a defect in luminal phosphatidylcholine hydrolysis? Carotenoid Research Interactive Group (CARIG) Conference, Invited speaker, Experimental Biology 2003, San Diego, CA.
  • Noh, S.K. and Koo, S.I. Milk sphingomyelin (SM) is a more potent inhibitor that egg SM of intestinal cholesterol absorption in rats. FASEB J. 17:A754, 2003.
  • Koo, S.I., Wang, S. & Noh, S.K. (+)-Catechin is a potent inhibitor than resveratrol of the intestinal absorption of cholesterol in ovariectomized rats. FASEB J. 16: A645, 2002.
  • Noh, S.K. & Koo, S.I. Luminal infusion of sphingomyelin lowers the lymphatic absorption of cholesterol and alpha-tocopherol in rats. FASEB J. 16: A632, 2002.
  • Wang, S., Noh, S.K. & Koo, S.I. Green tea epigallocatechin gallate inhibits the luminal hydrolysis and lymphatic output of phosphatidycholine and lowers the lymphatic absorption of fat and ?-tocopherol in ovariectomized rats. FASEB J. 16: A644, 2002.
  • Koo, S.I., Noh, S.I., and Jiang,Y. (+)-Catechin lowers the lymphatic absorptions of cholesterol in rats.FASEB J.15:757.5, 2001.
  • Löest, H, Noh, S.K., and Koo, S.I. Intraduodenal infusion of green tea decreases the lymphatic absorption of cholesterol in ovariectomized rats. FASEB J. 15: 757.3, 2001.
  • Noh, S.K. and Koo, S.I. The lymphatic output of retinol is decreased in marginally zinc deficient rats infused intraduodenally with ß-carotene. FASEB J. 15:740.9, 2001.
  • Zou, W., Noh, S.K., Loest, L., and Koo, S.I. Epigallocatechin gallate and quercetin lower the lymphatic absorption of cholesterol in rats. FASEB J. 15:757.4, 2001.
  • Wang, S., Noh, S.K., and Koo, S.I. Green tea catechins inhibit pancreatic phospholipase A2 activity in vitro.FASEB J. 15:LB305, 2001.
  • Koo, S.I., Zou, W., Noh, S.K., Gross, K.L., and Owen, K.Q. Dietary carnitine increases the liver level and biliary secretion of a-tocopherol (aTP) in ovariectomized (OX) rats. FASEB J. 14:357.7, 2000.
  • Noh, S.K. and Koo, S.I. Enteral lysophosphatidylcholine (LPC) restores the lymphatic absorption of retinol (ROH) and a-tocopherol (aTP) in zinc deficient (ZD) rats. FASEB J. 14:360.6, 2000.
  • Jiang, Y.Z., Noh, S.K., and Koo, S.I. Egg phosphatidylcholine (PC) decreases the lymphatic absorption of cholesterol in rats. FASEB J. 14:175.2, 2000.
  • Zou, W., Koo, S.I., Noh, S.K., Gross, K.L., and Owen, K.Q. Dietary carnitine enhances the lymphatic absorption of a-tocopherol (aTP) in ovariectomized (OX) rats. FASEB J. 14:357.8, 2000.
  • Koo, S.I., Zou, W., Noh, S.K., Gross, K.L., and Owen, K.Q. Dietary carnitine increases the liver level and biliary secretion of a-tocopherol in ovariectomized rats. FASEB J.14:A505.
  • Koo, S.I., Noh, S.K. and Zou, W. Enteral phosphatidylcholine (PC) infusion lowers the lymphatic absorption of a-tocopherol in zinc-deficient rats with bile diversion. FASEB J.13:214.16, 1999.
  • Noh, S.K. and Koo, S.I. Marginal zinc deficiency lowers the lymphatic absorption of ?-tocopherol (?TP) and enteral infusion of phosphatidylcholine (PC) further lowers (TP absorption. FASEB J.13:214.16, 1999.
  • Koo, S.I. and Noh, S.K. Estradiol replacement (ESR) elevates the liver levels and biliary secretion of phospholipid 22:6 (DHA) and a-tocopherol ((TP) in ovariectomized (OX) rats fed soybean oil. FASEB J. 12:A840, 1998.
  • Noh, S.K. and Koo, S.I. Feeding of a marginally low level of dietary zinc lowers the concentrations of ?-tocopherol (aTP) in selected tissues.FASEB J.12:A217, 1998.
  • Noh, S.K., Kim, E.S., Chung, H.J. and Koo, S.I. Enteral infusion of glucose or alanine plus glycine, not glutamine, increases the absorption of 14C-triolein and alpha-tocopherol (?TP). The increase is associated with a rise in lymphatic glucose output. FASEB J. 11:A382, 1997.
  • Chung, H.J., Noh, S.K., Chu, A and Koo, S.I. Estradiol (ES) replacement in ovariectomized rats elevates markedly serum a-tocopherol (aTP), with a selective increase in HDL aTP. FASEB J. 11:A412, 1997.
  • Koo, S.I., Chung, H.J., and Noh, S.K. The lymphatic absorption of a-tocopherol (aTP) and serum HDL aTP are markedly increased by estradiol replacement in ovariectomized rats. The 16th International Congress of Nutrition Abstracts 117: PM186, 1996.
  • Noh, S.K and Koo, S.I. Intraduodenal phosphatidylcholine (PC) infusion restores fully the lymphatic absorption of lipids in ovariectomized (OX) rats with estrogen replacement (ER).FASEB J. 10:A521, 1996.
  • Kim, E.S., Noh, S.K. and Koo, S.I. Direct evidence for the impaired lymphatic absorption of ?-tocopherol ((TP) in marginally zinc deficient (ZD) rats. FASEB J. 10:A528, 1996.
  • Koo, S.I. and Ahn, J. Lymphatic absorption of vitamin A and fatty acid is restored to normal in zinc deficient rats by intraduodenal infusion of phosphatidylcholine. FASEB J. 9:A166, 1995.
  • Yang, L. and Koo, S.I. Ovariectomy results in increases in body weight and fat and estradiol replacement elevates serum and tissue free fatty acids (FFAs) in ovariectomized rats. FASEB J. 9:A466, 1995.
  • Ahn, J., Choi, I.W. and Koo, S.I. Effect of zinc deficiency on the plasma clearance and hepatic uptake of 3H-retinyl palmitate (ROP) in rats. FASEB J. 8:A2572 1994.
  • Yang, L., Frye, A. and Koo, S.I. Effects of estrogen replacement on the lymphatic absorption of lipids in ovariectomized rats. FASEB J. 8:A4264, 1994.
  • Koo, S.I. and Yang, L. Estradiol replacement delays induction of copper deficiency and copper repletion increases plasma HDL-cholesterol in ovariectomized rats. FASEB J. 7: A803, 1993.
  • Ahn, J. and Koo, S.I. The lymphatic absorption of retinol and secretion of phospholipid are impaired in zinc and essential fatty acid deficient rats. FASEB J. 7:A511, 1993.
  • Koo, S.I. and Ahn, J. The effect of zinc status on the intestinal absorption and tissue uptake of 3H-retinol in rats. XV International Congress of Nutrition (Adelaide, Australia) 15:818, 1993.
  • Koo, S.I. and Lee, C.C. Plasma clearance of cholesterol via VLDL does not reflect an increase in the liver synthesis of cholesterol in copper deficient rats. FASEB J. 6:A1106, 1992.
  • Wang, S. and Koo, S.I. Evidence for distinct metabolic utilization of stearic acid in the liver, compared with palmitic and oleic acid. FASEB J. 6:A1384, 1992.
  • Brenner, G.M. and Koo, S.I. Interactive effects of copper status and estradiol replacement on HDL cholesterol and copper levels in female rats. FASEB J. 6:A1096, 1992.
  • Koo, S.I., Peterson, D.F. and Mason, P.A. Effect of dietary copper and sucrose on catecholamine concentrations in the adrenal medulla. FASEB J. 5:A584, 1991.
  • Koo, S.I., Lee, C.C. and Sabin, L. Effect of copper deficiency on the hepatic synthesis and rate of secretion of cholesterol in male rats. FASEB J. 4:A1545, 1990.
  • Peterson, D.F., Koo, S.I. and Lee, C.C. Interactive effects of dietary copper and carbohydrates on serum cholesterol and minerals. FASEB J. 4:A1550, 1990.
  • Ray, D.B., Lee, C.C and Koo, S.I. Hepatic apolipoprotein A-I mRNA is decreased in copper-deficient rats. FASEB J. 3:A1062, 1989.
  • Carter, J., Koo, S. and Goljan, E. Evaluation of different dietary zinc levels on serum components in rabbits.FASEB J. 3:A1080, 1989.
  • Rhee, H.M., Peterson, D.F. and Koo, S.I. Effect of forced running stress on plasma catecholamines and cholesterol: an involvement of opioid receptor. Am. J. Hypertension 2(5):72a, 1989.
  • Koo, S.I., Lee, C.C., Scott, R.L. and Stone, W.L. Plasma clearance of human 125I-low density lipoproteins (LDL) in copper-deficient rats. FASEB J. 3:A1062, 1989.
  • Lee, C.C. and Koo, S.I. Effect of menhaden fish oil on plasma cholesterol in copper-deficient rats. FASEB J. 3:A357, 1989.
  • Lee, C.C. and Koo, S.I. Compositional characterization of three plasma high density lipoprotein (HDL) subclasses in copper-deficient rats. FASEB J. 2:A854, 1988.
  • Koo, S.I., Lee, C. and Norvell, J.E. Copper deficiency decreases intestinal absorption of cholesterol and postheparin lipase activities, but does not alter chylomicron clearance. FASEB J. 2:A853, 1988.
  • Brenner, G and Koo, S.I. Effect of estradiol on serum HDL-cholesterol, and serum and tissue distribution of zinc and copper in ovariectomized rats. FASEB J. 2:A1218, 1988.
  • Lee, C.C, Koo, S.I. and Norvell J.E. Effect of zinc deficiency on postheparin, adipose and muscle lipoprotein lipase activities in the rat. Fed. Proc. 46:1472, 1987.
  • Koo, S.I. and Lee, C.C. Composition of high-density lipoproteins (HDL) and HDL subclasses of marginally zinc-deficient rats. Fed. Proc. 46:1472, 1987.
  • Lee, C.C., Koo, S.I. and Norvell, J.E. Effect of marginal zinc deficiency on the apoprotein (Apo) B concentration of lymph chylomicrons. Fed. Proc. 45:974, 1986.
  • Carter, J.W. and Koo, S.I. Effect of zinc-deficient diets on the cardiovascular system in rabbits. Fed. Proc. 45:1083, 1986.
  • Koo, S.I., Norvell, J.E., Algilani, K. and Chow, J. Effect of marginal zinc deficiency on the lymphatic absorption of 14C-cholesterol. Fed. Proc. 45:974, 1986.
  • Koo, S.I., Algilani, K. and Norvell, J.E. Marginal zinc deficiency delays the rate of plasma clearance and hepatic uptake of lymph chylomicron 14C-cholesterol in the rat. Fed. Proc. 44:1505, 1985.
  • Algilani, K., Dodds, S., Koo, S.I. and Mercer, L.P. Relationship of zinc and copper with serum lipoprotein cholesterol and lecithin:cholesterol acyltransferase (LCAT) activity in the rats fed varying levels of histidine. Fed. Proc. 44:1508, 1985.
  • Carter, J.W., Koo, S.I., Miller-Hardy, D.K. and Goljan, E.F. Effect of dietary Aroclor 1254 (PCBs) on atherosclerosis in pigeons. Fed. Proc.44:1158, 1985.
  • Koo, S.I., Algilani, K., Hung, C.P., Henderson, D.A. and Norvell, J.E. Effect of marginal zinc deficiency on the intestinal absorption of 14C-cholesterol and composition of lymphatic chylomicrons. Fed. Proc. 43:685, 1984.
  • Henderson, D.A., Koo, S.I., Algilani, K and Algilani, A. Altered morphology of chylomicrons in jejunum and blood of marginally zinc-deficient rats. Fed. Proc. 43:823, 1984.
  • Carter, J.W., Mercer, L.P. and Koo, S.I. Dietary PCBs (Aroclor 1254) produces hypercholesterolemia in Fischer rats. Southwestern Assoc. Toxicol. May, 1983.
  • Koo, S.I. Dietary linoleic acid reduces serum levels of zinc and HDL-cholesterol. Fed. Proc. 42:3104, 1983.
  • Koo, S.I. Effect of nutritional status of zinc on the concentration of high-density lipoprotein cholesterol. Fed. Proc. 40:839, 1981.
  • Koo, S.I. and Williams, D.A. New evidence for positive correlation between serum zinc and HDL-cholesterol and Its significance in coronary heart disease. Am. Chem. Soc. (March). 5, 1981.
  • Koo, S.I., Fullmer, C.S. and Wasserman, R.H. Intestinal absorption and retention of 109Cd. Fed. Proc. 37:405, 1978.

Patents

  • Koo, S.I., Hua, D., and Noh, S.K. Compounds Affecting Cholesterol Absorption. U.S. Patent Number 6,727,277. (Issued April 27, 2004), U.S. Patent and Trademark Office.
  • Koo, S.I. Phosphatidylcholine Compositions and Methods to Reduce Intestinal Absorption and Plasma Levels of Cholesterol. US Patent Number 6,248,728, Issued June 19, 2001. U.S. Patent and Trademark Office.
  • Koo, S.I., Owen, K., Noh, S., Gross, K., and Zou, W. Supplemental L-Carnitine Enhances the Intestinal Absorption and Body status of Vitamin E. S/N 60/188,419. U.S. Patent and Trademark Office, Application filed March 10, 2000.
  • O'Quinn, P., Koo, S.I., Nelssen, J., Goodband, R., Tokach, M., and Owen, K. Use of Modified Tall Oil or Conjugated Linoleic Acid in Combination to Improve Body Composition and Health Status. S/N 09/608,817. U.S. Patent and Trademark Office, Application review pending.
  • Hua, D.H., Koo, S.I., and Noh, S.K. Inhibitors of Lymphatic Absorption of Cholesterol, New Drugs for Lowering Intestinal Absorption of Cholesterol: (4aS,6aR,12bS)-2H-11-Chloro-1,3,3,4a-12b-octahydro-4,4,6a,12b-tetramethyl-benzo[a]xanthene-9-10-diol and its Derivatives. Disclosure filed by KSURF, June 5, 2002.
News and Updates

June 16, 2008 – Research Study
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February 5, 2008 - "What's Happening"
The Spring-Fall 2007 edition of the Department of Nutritional Sciences newsletter, "What's Happening," is available as a pdf here.

 

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