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Ji-Young Lee, Ph.D., FAHA

Office: 211C Advanced Technology Laboratory
TEL: 860-486-1827
E-mail: ji-young.lee@uconn.edu

EDUCATION

  • Ph.D. 2002 Major in Nutrition, University of Nebraska-Lincoln
  • M.S. 1998 Major in Nutritional Science and Dietetics, University of Nebraska-Lincoln
  • M.S. 1994 Major in Food Chemistry, Kyung Hee University, Seoul, South Korea
  • B.S. 1991 Major in Foods and Nutrition, Kyung Hee University, Seoul, South Korea

PROFESSIONAL EXPERIENCE

  • Associate Professor (July 2010 – Present),
    Department of Nutritional Sciences, University of Connecticut
  • Assistant Professor (July 2005 – June 2010),
    Department of Nutrition and Health Sciences, University of Nebraska-Lincoln
  • Postdoctoral Fellow (June 2002 – June 2005),
    Department of Pathology, Wake Forest University School of Medicine

HONORS/AWARDS

  • Fellow, American Heart Association, Arteriosclerosis, Thrombosis, and Vascular Biology Council, May 2013.
  • American Society for Nutrition, 1st Korean Nutrition Society Award, 2011.
  • Recognition of Junior Faculty for Excellence in Research, Agriculture Research Division, University of Nebraska-Lincoln, 2009.
  • Luella Selover Memorial Scholarship, 2001.
  • Widaman Trust Distinguished Graduate Assistant Award, 2000.
  • Undergraduate Scholarship, Kyung Hee University, Seoul, South Korea, 1989.

NOTABLE PROFESSIONAL ACTIVITIES

  • Grant reviewer, NIH ZRG1 EMNR-V, July 2016 (ad hoc).
  • Grant reviewer, American Heart Association Lipid Bsc 2, April 2016.
  • Grant reviewer, NIH Integrative Nutrition and Metabolic Processes (INMP) Study Section, February 2016 (ad hoc).
  • Grant reviewer, American Heart Association Lipid Bsc 2, October 2015.
  • Grant reviewer, NIH Integrative Nutrition and Metabolic Processes (INMP) Study Section, October 2015 (ad hoc).
  • Grant reviewer, American Heart Association Lipid Bsc 2, April 2015.
  • Grant reviewer, American Heart Association Lipid Bsc 2, October 2014.
  • Grant reviewer, American Heart Association Strategically Focused Research Networks (SFRN) grant, May 2014.
  • Grant reviewer, American Heart Association Lipid Bsc 2, April 2014.
  • Grant reviewer, NIH NCCAM Special Emphasis Panel ZAT1 SM25, March 2012.
  • Editorial board member, Journal of Nutritional Biochemistry, July 2010-present.
  • Editorial board member, Journal of Human Nutrition and Food Science, July 2013-present.
  • Review editor, Journal of Medicinal Food, January 2011-present.
  • Editorial board member, Nutrition Research and Practice, January 2016-present.
  • Editorial board member, Journal of Physiobiochemical Metabolism, May 2012-present.
  • Editorial board member, Journal of Nutrition and Intermediary Metabolism, July 2014-present.
  • Editorial board member, Korean Journal of Nutrition, May 2011-present.
  • Editorial board member, Journal of Nutrition and Health, May 2011-present.
  • Editorial board member, Endocrinology & Diabetes Research, May 2012-present.
  • Editorial board member, Food and Nutrition Sciences, August 2012-March 2014.

SOCIETY MEMBERSHIPS

  • Premium member, American Heart Association (Since 2010)
  • Member, Korean Society for Food Science and Nutrition (Since 2011)
  • Member, American Association for the Advancement of Science (Since 2005)
  • Regular Member, American Society for Nutrition (Since 2006)
  • Early Career Member, American Heart Association, Council of Atherosclerosis, Thrombosis and Vascular Biology (2003-2010)
  • Associate Member, American Society for Nutritional Science (2003-2005)
  • Student Member, American Society for Nutritional Sciences (1998-2002)
  • Registered Dietitian, Korean Society for Registered Dietitian (Since 1991)

RESEARCH INTEREST

Dysregulation of energy metabolism, chronic inflammation and dyslipidemia are major contributors to the development of obesity-associated disease such as insulin resistance, non-alcoholic fatty liver disease, type 2 diabetes and cardiovascular disease. My research focuses on the identification of molecular mediators that are involved in lipid metabolism and inflammatory signaling pathways, and on the elucidation of molecular mechanisms by which dietary factors, such as blue-green algae, berries, phospholipids and astaxanthin, play regulatory roles in the integration of lipid metabolism and inflammation. The primary foci of my research program elegantly address a new concept of “immunometabolism” to link inflammatory signaling pathways to energy metabolism using state of the art molecular techniques and cell bioenergetics tools in various cells and animal models. In addition, another research focus lies on the identification of molecular targets that critically impact on the process of liver fibrosis with attempts to develop preventive and therapeutic strategies for liver fibrosis. In particular, how dietary factors regulate histone deacetylases as an epigenetic mode of action for the regulation of gene transcription in metabolic, inflammatory, and fibrogenic pathways are actively underway in my laboratory.

research focus

PUBLICATIONS

Peer-Reviewed Articles

  1. L. Xie, S. Lee, T. M. Vance, Y. Wang, B. Kim, J. Lee, O. K. Chun, B. W. Bolling. Bioavailability of anthocyanins and colonic polyphenol metabolites following consumption of aronia berry extract. Food Chem 2016; (In press). 
  2. T.X. Pham, J. Lee. Anti-inflammatory effect of Spirulina platensis in macrophages is beneficial for adipocyte differentiation and maturation by inhibiting Nuclear factor-kB pathway in 3T3-L1 adipocytes. J Med Food 2016; (In press). Epub ahead of print on May 20, 2016.
  3. S. Patel, A. Akalkotkar, J. J. Bivona III, J. Lee, Y. Park, M. Yu, S. Colpitts, M. Vajdy. Vitamin A or E and a catechin synergize as vaccine adjuvant to enhance immune responses in mice through induction of early IL-15 but not IL-1b. Immunology 2016; (In press). Epub ahead of print on May 2, 2016.
  4. M. Surendran-Nair, A. Kollanoor-Johny, S. Ananda-Baskaran, C. Norris, J. Lee, K. Venkitanarayanan. Selenium reduces enterohemorrhagic Escherichia coli O157:H7 verotoxin production and globotriaosylceramide receptor expression on host cells. Future Microbiol 2016; (In press). Epub ahead of print on May 18, 2016.
  5. B. Kim, C. Farruggia, C. S. Ku, T. X. Pham, Y. Yang, Casey J. Wegner, N. J. Farrell, E. Harness, Y. Park, Sung I. Koo, J. Lee. Astaxanthin, a xanthophyll carotenoid, inhibited inflammation and fibrosis in the adipose and the liver of diet-induced obesity and liver fibrosis mice. J Nutr Biochem 2016; (In press). Epub ahead of print on March 2, 2016.
  6. Y. Yang, M. Bae, B. Kim, Y. Park, S. I. Koo, J. Lee. Astaxanthin prevents and reverses the activation of mouse primary hepatic stellate cells. J Nutr Biochem 2016; 29:21-26. Epub ahead of print on Nov 24, 2015. (PMID: 26895661)
  7. C. E. Dugan, D. Aguilar, Y. Park, J. Lee, M-L. Fernandez. Dietary consumption lowers systemic inflammation and liver enzymes in typically low-dairy consumers with clinical characteristics of metabolic syndrome. J Am Coll Nutr 2016; 35:255-261. Epub ahead of print on Nov 23, 2015. (PMID: 26595359)
  8. G. Karim., K. Menzies, D. Ryu, C. J. Wegner, X. Wang, E. R. Ropelle, N. Moullan, H. Zhang, A. Perino, V. Lemos, B. Kim, Y. Park, P. Alessandra, T. X. Pham, Y. Yang, C. S. Ku, S. I. Koo, A. Fomitchova, C. Canto, K. Schoonjans, A. A. Sauve, J. Lee*, J. Auwerx. Eliciting the mitochondrial unfolded protein response via NAD+ repletion prevents fatty liver disease. Hepatology 2016; 63:1190-1204. Epub ahead of print on Sept 25, 2015. (PMID: 26404765) * Shared corresponding authorship.
  9. S. Lee, B. Kim, S. D. Y, T. Vance, J.S Lee, J. Lee, S. I. Koo, D.O. Kim, M. H. Drissi, O. K. Chun. Relationship between oxidative stress and bone mass in obesity and effects of berry supplementation on bone remodeling in obese male mice: an exploratory study.  J Med Foods 2015; 18:476-482. Epub ahead of print on Sept 8, 2014. (PMID: 25198411)
  10. C. S. Ku, B. Kim, T. X. Pham, Y. Yang, Y. Park, C. L. Weller, T. Carr, J. Lee. Hypolipidemic effect of a blue-green alga (Nostoc commune) is attributed to its nonlipid fraction by decreasing intestinal cholesterol absorption in C57BL/6J mice. J Med Food 2015; 18:1214-1222. Epub ahead of print on July 10, 2015. (PMID: 26161942)
  11. C. S. Ku, B. Kim, T. X. Pham, Y. Yang, C. J. Wegner, Y. Park, M. Balunas, J. Lee. Blue-green algae inhibit the development of atherosclerotic lesions in apolipoprotein E knockout mice. J Med Food 2015; 18:1299-1306. Epub ahead of print on Nov 13, 2015. (PMID: 26566121)
  12. M-Y. Chung, E. Mah, C. Masterjohn, S. K. Noh, H. J. Park, R. M, Clark, Y. Park, J. Lee, R. S. Bruno. Green tea lowers hepatic COX-2 and prostaglandin E2 in rats with dietary fat-induced nonalcoholic steatohepatitis. J Med Food 2015; 18:648-655. Epub ahead of print on Dec 2, 2014. (PMID: 25453513) 
  13. T. Benn, B. Kim, Y. Park, Y. Yang, T. X. Pham, C.S. Ku, E. Harness, C. Farruggia, E. Harness J. A. Smyth, J. Lee. Polyphenol-rich blackcurrant extract exerts hypolipidemic and hypoglyceridemic effects in mice fed a diet containing high fat and cholesterol. Br J Nutr 2015: 113:1697-1703. (PMID: 25899149)
  14. Y. Yang, B. Kim, Y. Park, S. I. Koo, J. Lee. Astaxanthin prevents transforming growth factor b1-induced pro-fibrogenic gene expression by inhibiting Smad3 activation in hepatic stellate cells. Biochimica Biophysica Acta 2015; 1850:178-185. (PMID: 25450180) 
  15. Y. Yang, T. X. Pham, C. J. Wegner, B. Kim, C. S. Ku, Y. Park, J. Lee. Astaxanthin lowered plasma triglyceride and increased hepatic antioxidant gene expression in diet-induced obesity mice. Br J Nutr 2014; 112:1797-1804. (PMID: 25328157)
  16. T. Benn, B. Kim, Y. Park, C. J. Wegner, E. Harness, T-G. Nam, D-O. Kim, J. S. Lee, J. Lee. Polyphenol-rich blackcurrant extract prevents inflammation in diet-induced obesity mice. J Nutr Biochem 2014; 25:1019-1025. (PMID: 25034502)
  17. W. Sittiwong, D. K. Zinnel, R. J. Fenton, D. Marshall, C. F. Story, B. Kim, J. Lee, R. Powers, R. G. Barletta, P. H. Dussault. Development of cyclobutene- and cyclobutane-functionalized fatty acids with inhibitory activity against Mycobacterium tuberoculosis. ChemMedChem 2014; 9:1838-1849. (PMID: 24902951)
  18. C. J. Andersen, J. Lee, C. N. Blesso, T. P. Carr, M-L. Fernandez. Egg intake during carbohydrate restriction alters peripheral blood mononuclear cell inflammation and cholesterol homeostasis in metabolic syndrome. Nutrients 2014; 6:2650-2667. (PMID: 25045936)
  19. Y. Yang, Y. Park, B. Kim, J. Lee. Long-term effect of blue-green algae on lipid metabolism in C57BL/6J mice. J Nutr Health and Food Sci 2014; 2:1-6. (PMID: 25614902)
  20. S. Lee, B. Kim, Y. Yang, T. X. Pham, Y. Park, J. Manatou, S. I. Koo, O. K. Chun, J. Lee. Berry anthocyanins suppress the expression and secretin of pro-inflammatory mediators in macrophages by inhibiting nuclear translocation of NF-kB independent of NRF2-mediated mechanism. J Nutr Biochem 2014; 25:404-411. (PMID: 24565673)
  21. C. Masterjohn, Y. Park, J. Lee, S. K. Noh, R. S. Bruno. Dietary fructose feeding increases adipose methylglyoxal accumulation in association with low expression and activity of glyoxalase-2. Nutrients 2013; 5:3311-3328. (PMID: 23966111)
  22. Y. Yang, B. Kim, J. Lee. Astaxanthin: structure, metabolism, and health benefits. J Hum Nutr Food Sci 2013; 1:1003 (1-11). 
  23. C. Masterjohn, E. Mah, Y. Park, R. Pei, J. Lee, J. E. Manatou, R. S. Bruno. Acute glutathione depletion induces hepatic methylglyoxal accumulation by impairing its detoxification to D-lactate. Expt Biol Med 2013; 238:360-369. (PMID: 23760001)
  24. C. J. Andersen, C. N. Blesso, J. Lee, J. Barona, D. Shah, M. J. Thomas, M. L. Fernandez. Egg consumption during carbohydrate restriction modulates HDL lipid composition and increases the cholesterol-accepting capacity of serum in metabolic syndrome. Lipids 2013; 48:557-567. (PMID: 23494579)
  25. B. Kim, Y. Park, C. J. Wegner, B. W. Bolling, J. Lee. Polyphenol-rich chokeberry extract regulates the expression of genes for lipogenesis and cholesterol transport in Caco-2 cells. J Nutr Biochem 2013; 24:1564-1570. (PMID: 23517916)
  26. B. Kim, C. S. Ku, T. X. Pham, Y. Park, D. A. Martin, L. Xie, J. Lee, B. W. Bolling. Aronia melanocarpa (chokeberry) polyphenol rich extract improves antioxidant function and reduces total plasma cholesterol in apolipoprotein E knockout mice. Nutr Res 2013; 33:406-413. (PMID: 23684442)
  27. C. S. Ku, Y. Yang, Y. Park, J. Lee. Health Benefits of blue-green algae: Prevention of cardiovascular disease and nonalcoholic fatty liver disease. J Med Food 2013; 16:103-111. (PMID: 23402636)
  28. C. S. Ku, T. X. Pham, Y. Park, B. Kim, M. Shin, I. Kang, J. Lee. Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-kB pathway in macrophages and splenocytes. Biochimica Biophysica Acta 2013; 1830:2981-2988. (PMID: 23357040)
  29. C. J. Wegner, B. Kim, J. Lee. Trust your gut: Galvanizing nutritional interest in intestinal cholesterol metabolism for protection against cardiovascular diseases. Nutrients 2013; 5: 208-222. (PMID: 23325147)
  30. T. X. Pham, J. Lee. Dietary regulation of histone acetylase and deacetylase for the prevention of metabolic diseases. Nutrients 2012; 4:1868-1886. (PMID: 23363995)
  31. J. Barona, C. N. Blesso, C. J. Andersen, Y. Park, J. Lee, M-L. Fernandez. Grape consumption increases anti-inflammatory markers and upregulates peripheral nitric oxide synthase in the absence of dyslipidemias in men with metabolic syndrome. Nutrients 2012; 4:1945-1957. (PMID: 23222963)  
  32. Y. Park, T. X. Pham, J. Lee. Lipopolysaccharide represses the expression of ATP-binding cassette transporter G1 and scavenger receptor class B, type I in murine macrophages. Inflamm Res 2012; 61:465-472. (PMID: 22240665)
  33. C. S. Ku, Y. Park, S. L. Coleman, J. Lee. Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages. J Nutr Biochem 2012; 23: 1271-1276. (PMID: 22209005)
  34. J. Lee, Y. Park, S. I. Koo. ATP binding cassette transporter A-I and HDL metabolism: Effects of fatty acids. J Nutr Biochem 2012; 23:1-7. (PMID: 21684139)
  35. J. E. Kim, R. M. Clark, Y. Park, J. Lee, M. L. Fernandez. Lutein decreases oxidative stress and inflammation in liver and eyes of guinea pigs fed a hypercholesterolemic diet. Nutr Res Pract 2012; 6:113-119. (PMID: 22586499)
  36. H. J. Park, J. Lee, M.Y. Chung, Y. Park, A. Bower, S. I. Koo, C. Giardina, R. S. Bruno. Green tea extract suppressed NFkB activation and inflammatory responses in a diet-induced obese model of nonalcoholic steatohepatitis. J Nutr 2012; 142:57-63. (PMID: 22157544)
  37. J. J. Jones, Y. Park, J. Lee, R. H. Lerman, M. L. Fernandez. A Mediterranean-style, low-glycemic-load, diet reduces the expression of HMG-CoA reductase in mononuclear cells and correlated with decreases in insulin in women with metabolic syndromes. Nutr Res 2011; 31:659-664. (PMID: 22024489)
  38. Y. Yang, J. M. Seo, A. Nguyen, T. X. Pham, H. J. Park, Y. Park, R. S. Bruno, J. Lee. Astaxanthin from Haematococcus pluvialis lowered plasma lipid concentrations and increased antioxidant defense in apolipoprotein E knockout mice. J Nutr 2011; 141:1611-1617. (PMID: 21734060)
  39. S. L. Coleman, Y. Park, J. Lee. Unsaturated fatty acids repress the expression of adipocyte fatty acid binding protein via the modulation of histone deacetylation in RAW 264.7 macrophages. Eur J Nutr 2011; 50:323-330. (PMID: 21046125) 
  40. J. M. Seo, J. Lee, G. E. Ji, J. C. You. Down-regulation of ATP-binding cassette transporter G1 expression by unmethylayed CpG oligodeoxynucleotides (CpG ODNs) in RAW 264.7 macrophages. Expt Mol Med 2011; 43:510-516. (PMID: 21737995)
  41. S. J. Ehlers, S. M. Larson, H. E. Rasmussen, Y. Park, J. Lee.  High-density lipoprotein metabolism in human apolipoprotein B transgenic/brown adipose tissue deficient mice, a model of obesity-induced hyperinsulinemia. Appl Physiol Nutr Metab 2011; 36:313-322. (PMID: 21574779) 
  42. Y. Yang, Y. Park, J. Lee. In vitro and in vivo safety assessment of edible blue green algae, Nostoc commune var. sphaeroides Kützing and Spirulina plantensis. Food Chem Toxicol 2011; 49:1560-1564. (PMID: 21473896) 
  43. C. S. Ku, H. E. Rasmussen, Y. Park, E. D. Jesch, J. Lee. Unsaturated fatty acids repress the expression of ATP-binding cassette transporter A1 in HepG2 and FHs 74 Int cells. Nutr Res 2011; 31:278-285. (PMID: 21530801)   
  44. H. J. Park, D. A. DiNatale, M-Y. Chung, Y. Park, J. Lee, S. I. Koo, M. O’Connor, J. E. Manautou, R. S. Bruno. Green tea extract attenuated hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice. J Nutr Biochem 2011; 22:151-159. (PMID: 20655714)
  45. V. L. Schlegel, R. Zbasnik, B. H. Lee, T. P. Carr, J. Lee, C. L. Weller, S. L. Cuppett. Characterization of potential health promoting lipids in the co-products of de-flossed milkweed. J Food Chemistry 2010; 126:15-20.
  46. E. D. Jesch, J. M. Seo, T. P. Carr, J. Lee. Sitosterol reduces mRNA and protein expression levels of Niemann-Pick C1-Like 1 (NPC1L1) in FHs 74 Int cells. Nutr Res 2009; 29: 859-866. (PMID: 19963159)
  47. J. T. Hoi, C. L. Weller, V. L. Schlegel, S. L. Cuppet, J. Lee, T. P. Carr. Sorghum distillers dried grain lipid extract increases cholesterol excretion and decreases plasma and liver cholesterol concentration in hamsters. J Funct Food 2009; 1: 381-386.
  48. H. E. Rasmussen, I. Martinez, J. Lee, J. Walter. Alteration of the murine gastrointestinal microbiota by edible blue-green algae.  J Appl Microbiol 2009; 107: 1108-1118. (PMID: 19486425) 
  49. H. E. Rasmussen, K. R. Blobaum, E. D. Jesch, C. S. Ku, Y. Park, F. Lu, T. P. Carr, J. Lee. Hypocholesterolemic effect of Nostoc commune var sphaeroides Kützing, an edible blue-green alga.  Eur J Nutr 2009; 48:387-394. (PMID: 19404563)
  50. S. Shrestha, S. J. Ehlers, J. Lee, M-L. Fernandez, S. I. Koo.  Dietary green tea extract lowers plasma and hepatic triglyceride and decreases the expression of SREBP-1c mRNA and its responsive genes in fructose-fed ovariectomized rats.  J Nutr 2009; 139:640-645. (PMID: 19193814)
  51. A. Mulya, J. Lee, A. K. Gebre, E. Y. Boudyguina, S-K. Chung, T. L. Smith, P. L. Colvin, X. C. Jiang, J. S. Parks.  Initial Interaction of ApoA-I with ATP Binding Cassette Transporter A1 (ABCA1) Impacts in vivo metabolic fate of nascent HDL.  J Lipid Res 2008; 49:2390-2401. (PMID: 18583707)
  52. X. Zhu, J. Lee, J. M. Timmins, J. M. Brown, E. Y. Boudyguina, A. Mulya, A. K. Gebre, M. C. Willingham, E. M. Hiltbold, N. Mishra, N. Maeda, J. S. Parks.  Increased cellular free cholesterol in macrophage-specific Abca1 knockout mice enhances pro-inflammatory response of macrophages.  J Biol Chem 2008; 283:22930-22941. (PMID: 18552351)
  53. H. E. Rasmussen, K. R. Blobaum, Y. Park, S. J. Ehlers, F. Lu, J. Lee.  Lipid extract of Nostoc commune var. sphaeroides Kützing, a blue-green alga, inhibits the activation of sterol regulatory element binding proteins in HepG2 cells.  J Nutr 2008; 138:476-481. (PMID: 18287352)
  54. Y. Park, H. E. Rasmussen, S. J. Ehlers, K. R. Blobaum, F. Lu, V. L. Schlegal, T. P. Carr, J. Lee.  Repression of proinflammatory gene expression by lipid extract of Nostoc commune var sphaeroides Kützing, a blue-green alga, via inhibition of nuclear factor-κB in RAW 264.7 macrophages.  Nutr Res 2008; 28:83-91. (PMID: 19083393)
  55. Young-Nam Kim, J. Lee, J. A. Driskell. Marginal folate inadequacy observed in a group of young children in Kwangju, Korea.  Nutr Res and Practice 2007; 2:120-125. (PMID: 20535397)
  56. A. Mulya, J. Lee, A. K. Gebre, M. Thomas, P. L. Colvin, J. S. Parks.  Minimal lipidation of pre-b HDL by ABCA1 results in reduced activity to interact with ABCA1. Arterio Thromb Vasc Biol 2007; 27:1828-1836. (PMID: 17510466)
  57. J. Lee, R. Badeau, A. Mulya, E. Boudyguina, A. K. Gebre, T. L. Smith, J. S. Parks. Functional lecithin:cholesterol acyltransferase (LCAT) deficiency in human apolipoprotein A-I transgenic scavenger receptor class B, type I knockout mice. J Lipid Res 2007; 48:1052-1061. (PMID: 17272829)
  58. J. Lee, J. M. Timmins, A. Mulya, T. L. Smith, Y. Zhu, E. M. Rubin, P. L. Colvin, J. S. Parks.  Plasma HDL in human apoA-I transgenic-Abca1 knockout mice undergo normal intravascular remodeling but are hypercatabolized by the kidney. J Lipid Res 2005; 46:2233-2245. (PMID: 16024913)  
  59. J. M. Timmins, J. Lee, E. Boudyguina, K. Kluckman, L. R. Brunham, A. Mulya, A. K. Gebre, J. Coutinho, P. L. Colvin, T. L. Smith, M. R. Hayden, N. Maeda, J. S. Parks. Targeted inactivation of hepatic ABCA1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apolipoprotein A-I. J Clin Invest 2005; 115:1333-1342. (PMID: 15841208)
  60. J. Lee, T. P. Carr. Dietary fatty acids regulate the expression of ABCA5 and ABCG8 in hamsters. Nutr Res 2005; 25:167-175.
  61. J. Lee, J. S. Parks. ATP-binding cassette AI (ABCA1) and its role in HDL formation. Curr Opin Lipidol 2005; 16:19-25. (PMID: 15650559)
  62. J. Lee, T. P. Carr. Dietary fatty acids regulate acyl-CoA:cholesterol acyltransferase and cytosolic cholesteryl ester hydrolase in hamsters. J Nutr 2004; 134:3239-3244. (PMID: 15570019)
  63. J. Lee, L. Lanningham-Foster, E. Boudyguina, T. Smith, E. R. Young, P. Colvin, M. Thomas, J. S. Parks. 2004. Pre-beta high density lipoprotein has two metabolic fates in human apolipoprotein A-I transgenic mice. J Lipid Res 2004; 45:716-728. (PMID: 14729861)
  64. J. Lee, N. M. Lewis, S. E. Scheideler, T. P. Carr. Consumption of omega-3 fatty acid-enriched eggs and serum lipids in humans. J Nutraceuticals Funct Med Foods 2003; 4:3-13.
  65. R. L. Cowles, J. Lee, D. D. Gallaher, C. L. Stuefer-Powell, T. P. Carr. Dietary stearic acid alters gallbladder bile acid composition in hamsters fed cereal-based diets. J Nutr 2002; 132:3119-3122. (PMID: 12368404)
  66. T. P. Carr, G. Cai, J. Lee, C. L. Schneider.  Cholesteryl ester enrichment of plasma low- density lipoprotein in hamsters fed cereal-based diets containing cholesterol. Proc Soc Exp Biol Med 2000; 233:96-101. (PMID: 10632967)
  67. J. Lee, S. J. Koo. Effect of the addition of dietary fiber on the quality of Julpyun. J Kor Soc Food Sci 1994; 10(3):267-276.

Book Chapters

  1. T. X. Pham, J. Lee. Regulation of histone acetylation by bioactive food components for the prevention of chronic diseases. In: The Role of Nutrition and Metabolism on Epigenetic Regulation, F. Domann and E. Ho, eds. Taylor & Francis Group, CRC Press., 2014, p361-388.
  2. S. J. Ehlers, H. E. Rasmussen, J. Lee.  Lipids. In: Nutrition and Exercise Concerns of Middle Age, J. Driskell, eds. CRC Press., 2009, p 53-85.
  3. H. E. Rasmussen, J. Lee. Total Fats, Saturated Fats and Cholesterol. In: Sports Nutrition: Fats and Proteins, J. Driskell, eds. CRC Press., 2007, p 15-36.
  4. J. Lee, S. H. Mitmesser, T. P. Carr. Cellular cholesterol metabolism. In: Molecular Nutrition, J. Zempleni and H. Daniel, eds. CABI Publishing, Oxfordshire, U.K., 2003, p 309-319.

GRANTS

  • National Institute of Health (R01) 1R01DK108254-01, “Nutritional Transcriptomics Approach for the Role of Astaxanthin in Liver Fibrosis”, 9/25/2015-8/31/2019, $1,385,494.
    Role in project:  Principal Investigator
  • United States Department of Agriculture, AFRI, “Protective action of blackcurrant against obesity-associated inflammation: Linking macrophage plasticity to energy metabolism”, 12/01/2015-11/30/2018, $499,946.
    Role in project: Principal Investigator
  • National Institute of Health (R15) 1R15AT00861001, “Metabolites from edible blue-green algae for obesity-induced inflammation”, 12/15/2014-12/14/2017, $453,820 (my share $149,692).
    Role in project:  Co-investigator (PI: Marcy Balunas at UCONN)
  • Egg Nutrition Center, “Pilot study for evaluating the effect of egg phospholipids on the modulation of cholesterol homeostasis”, 7/01/2015-6/30/2016, $49,964.
    Role in project: Principal Investigator
  • Nutricia Research Foundation Research Grant, “Mechanistic understanding of the effect of cranberries on HDL metabolism”, 2/01/2015-1/31/2017, $64,375.
    Role in project: Principal Investigator
  • University of Connecticut Research Excellence Program, “Gene therapy for the prevention of liver fibrosis”, 3/15/2015-3/14/2016, $24,875.
    Role in project:  Principal Investigator
  • University of Connecticut Scholarship Facilitation Fund, “Regulation of adipose tissue fibrosis by astaxanthin”, 1/01/2016-12/31/2016, $2,000.
    Role in project:  Principal Investigator
  • United States Department of Agriculture, AFRI Seed Grant, CONS2014-06619, “Black elderberry as a novel functional food: Protection from HDL dysfunction in chronic inflammation”, 2/1/2015-1/31/2017, $149,857.
    Role in project: Co-Investigator
  • United States Department of Agriculture, Hatch CONS00872, “Transcriptional regulation of fatty acid binding protein 4 by dietary fatty acids in macrophages”, 10/01/2011-9/30/2016, $69,996.
    Role in project: Principal Investigator
  • United States Department of Agriculture, Multi-state Hatch, CONS00916, “W-3002, Nutrient Bioavailability—Phytonutrients and Beyond”, 10/01/2013-9/30/2018.
    Role in project: Principal Investigator
  • United States Department of Agriculture, AFRI (2012-67018-19290), “Bioactivity of astaxanthin in the prevention of hepatic inflammation”, 02/01/2012-01/31/2016, $459,646.
    Role in project: Principal Investigator
  • United States Department of Agriculture, AFRI Equipment Grant, CONS 2013-03483. “Use of a cell bioenergetics analyser to determine the effect of diet and bioactive food components on energy metabolism”, 12/01/2013-11/30/2015, $50,000.
    Role in project: Principal Investigator
  • United States Department of Agriculture, AFRI Predoctoral Fellowship, “Bioactivity of Spirulina platensis in the prevention of obesity-associated inflammation and insulin resistance by the modulation of histone deacetylases”, 1/01/2015-12/31/2015, $39,500.
    Role in project: Mentor (PI: Tho X. Pham) 
  • National Institute of Health (R21AT005152), “Evaluation of athero-protective role of blue-green algae”, 09/30/2009-08/31/2013, $275,000 direct costs ($112,365 F&A costs).
    Role in project:  Principal Investigator
  • State of Connecticut Department of Public Health, “The effect of chokeberry polyphenols on biomarkers of cardiovascular disease and antioxidant defense in former smokers”, 08/01/2012-5/31/2015, $417,076 (my share $87,000).
    Role in project: Co-PI (PI: Bradley Bolling, University of Connecticut)
  • Fuji Chemical Industry Co., “Role of astaxanthin in the prevention of hepatic stellate cell activation”, 07/01/2013-07/31/2014, $22,950.
    Role in project: Principal Investigator
  • University of Connecticut College of Agriculture and Natural Resources Equipment Competition, “Li-Cor Odyssey CLx Infrared Imaging System”, September 2012, $54,300.
    Role in project:  Principal Investigator
  • United States Department of Agriculture, Hatch CONS0080, “Efficacy of chokeberry polyphenols to reduce oxidative stress and atherosclerosis in the ApoE knockout mouse”, 10/01/2011-9/30/2016, $69,996.
    Role in project: Co-investigator (PI: Bradley Bolling, University of Connecticut)
  • United States Department of Agriculture, Multi-state Hatch, CONS00891, “N-3 polyunsaturated fatty acids and human health and disease”, 10/01/2012-9/30/2013.
    Role in project: Principal Investigator
  • Nutricia Research Foundation Research Grant, “Chokeberry polyphenols promote bone health by inhibiting inflammation-induced bone resorption”, 1/01/2013-12/31/2014, $63,181.
    Role in project: Collaborator
  • Connecticut Innovations, Advanced Technology Phase I STTR, “A novel vaccine against vaginal transmission of Chlamydia trachomatis”, 05/01/2014-11/30/2014, $40,000 direct costs (no F&A; my share $10,000).
    Role in project:  UCONN Investigator (PI: Michael Vajdy at EpitoGenesis)
  • United States Department of Agriculture, Multi-state Hatch, CONS00916, “Nutrient Bioavailability-Phytonutrients and Beyond”, 10/01/2012-9/30/2013, $1,000 for travel.
    Role in project: Principal Investigator
  • University of Connecticut Faculty Large Grant, “Regulatory mechanism for adipocyte fatty acid binding protein expression by fatty acids in macrophages”, 7/01/2011-6/30/2012, $25,000.
    Role in project:  Principal Investigator
  • National Egg Board, “Effect of egg intake on reverse cholesterol and insulin resistance in subjects classified with metabolic syndrome “, 09/01/2010-/31/2011, $127,315.
    Role in project: Co-investigator (PI: Maria-Luz Fernandez, University of Connecticut)
  • United States Department of Agriculture (NRI2007-35200-18298), National Research Initiative Competitive Grants Program, “Regulation of cholesterol absorption by plant sterol and stanol esters”, 08/01/2007-07/31/2011, $373,532 direct costs ($93,383 F&A costs) (My share: $148,691 direct costs, $37,172 F&A cost).
    Role in project: Co-Program director (PD: Timothy Carr, University of Nebraska-Lincoln)
  • United States Department of Agriculture (NRI2008-35200-18699), National Research Initiative Competitive Grants Program, “Evaluation of the Bioactivity of Green Tea in an Animal Model of Hepatic Oxidative Stress”, 01/01/2008-12/31/2010, $458,868 (Subcontract $23,921).
    Role in project: Collaborator (PI: Richard Bruno, University of Connecticut)
  • University of Connecticut Major Research Equipment Competition, “Preparative- and Mass Spectrometry-Based HPLC: Critical Analytical Tools To Establish A Bioactive Food Components and Health Core Laboratory”, $248,358.86.
    Role in project:  Collaborator
  • United States Department of Agriculture, Hatch (NEB-36-065), “Identification and Characterization of Bioactive Compounds with Cholesterol-lowering and Anti-inflammatory Properties from a Blue-green Alga Nostoc commune”, 01/01/2007-12/31/2012, $61,500. (Actual award $43,050 due to PI’s institutional change June 2010)
    Role in project: Principal Investigator
  • Nebraska Gateway for Nutrigenomics, University of Nebraska-Lincoln Vice Chancellor of Rersearch, “Regulation of histone deacetylase 3 by fatty acids”, 12/01/2009-11/30-2010, $11,480.
    Role in project: Principal Investigator
  • Faculty Seed Grant, University of Nebraska-Lincoln Research Council, “Modulation of cholesterol transporters in macrophages during inflammation”, 01/01/2009-12/31/2009, $10,000. 
    Role in project: Principal Investigator
  • Strategic Cluster Grant, University of Nebraska-Lincoln, Office of the Vice Chancellor for Research, “Pilot work in preparation for the R21 grant submission”, 02/20/2009-12/31/2009, $12,500. 
    Role in project:  Co-investigator (PI: Patrick Dussault, University of Nebraska-Lincoln)
  • National Science Foundation, SBIR Phase II (IIP-0724411), “An innovative photobioreactor for commercial production of Astaxanthin from genetically improved Haematococcus pluvialis strains”, 07/01/2007-06/30/2009, $448,550 (Subcontract $21,635).
    Role in project: Collaborator (PI: Fan Lu, Algaen Corporation)
  • Institute of Agricultural and Natural Resources Equipment Grant, University of Nebraska-Lincoln, Purchase of an infrared imaging systems for research and teaching purposes, 02/01/2008-06/01/2008, $51,950.
    Role in project:  Co-investigator
  • Faculty Seed Grant, University of Nebraska-Lincoln Research Council, “Transporter-mediated mechanism for the absorption of cholesterol and plant sterols”, 01/01/2007-12/31/2007, $10,000. 
    Role in project:  Principal Investigator
  • Interdisciplinary Grant, University of Nebraska-Lincoln Research Council, “Identification of bioactive compounds with cholesterol-lowering and anti-inflammatory properties in Nostoc commune, a blue-green alga”, 01/01/2007-12/31/2007, $20,000.
    Role in project:  Principal Investigator
  • Layman Award, University of Nebraska Foundation, “Regulation of ATP-binding cassette transporter A1 by fatty acids”, 05/01/2006-04/30/2007, $9,970.
    Role in project:  Principal Investigator
  • University of Connecticut, (National Institute of Health, 5R21AT001363-02), “Hypocholesterolemic action of green tea extracts”, 2006, $5,000 (subcontract). 
    Role in project:  Collaborator

TEACHING ACTIVITIES

Graduate Students and Postdocs

  • Siqi Hu, PhD student in Nutritional Sciences, University of Connecticut, In progress.
  • Dr. Tho Pham, Postdoc, University of Connecticut, January 2016 - Present.
  • Yoojin Lee, PhD student in Nutritional Sciences, University of Connecticut, In progress.
  • Minkyung Bae, PhD student in Nutritional Sciences, University of Connecticut, In progress.
  • Tho Pham, PhD in Nutritional Sciences, University of Connecticut, Completed in December 2015.
    Thesis title: Anti-inflammatory mechanism of Spirulina platensis: its regulation of histone deacetylases, endotoxin tolerance, and energy metabolism in macrophages.
  • Dr. Bohkyung Kim, Postdoc. University of Connecticut, October 2010 – May 2015.
  • Callie Ferruggia, MS in Nutritional Sciences, University of Connecticut, Completed in December 2014.
    Thesis title: The anti-inflammatory, antioxidant, and hepato-protective effects of astaxanthin. 
  • Tyler Benn, MS in Nutritional Sciences, University of Connecticut, Completed in August 2014.
    Thesis title: Prevention of Inflammation, Hyperglycemia, and Hypercholesterolemia by Polyphenol-Rich Blackcurrant Extract in obesity.
  • Cindy Yang, PhD in Nutritional Sciences, University of Connecticut, Completed in August 2014.
    Dissertation title: Health benefits of astaxanthin, a xanthophyll carotenoid: Protective functions against non-alcoholic fatty liver disease and steatohepatitis.
  • Chai Siah Ku, PhD in Nutritional sciences, University of Connecticut, Completed in August 2014.
    Dissertation title: Effect of edible blue-green Algae, Nostoc commune Var. Sphaeroides Kützing and Spirulina platensis,on the prevention of hyperlipidemia, inflammation, and atherosclerosis.
  • Casey Wegner, MS in Nutritional Sciences, University of Connecticut, Completed in May 2014.
    Thesis title: Nicotinamide riboside’s impact on lipid metabolism in apolipoprotein E deficient mice.
  • Chai Siah Ku, MS in Nutrition, University of Nebraska-Lincoln, Completed in August 2010.
    Thesis title: Regulation of ATP binding cassette transporter A1 and G1 expression by fatty acids.
  • Sara Coleman, MS in Nutritional Sciences, University of Nebraska-Lincoln, Completed in May 2010.
    Thesis title: Unsaturated fatty acids repress the expression of adipocyte fatty acid-binding protein, aP2, in RAW 264.7 macrophage.
  • Heather Rasmussen, PhD in Nutrition, University of Nebraska-Lincoln, Completed in December 2008.
    Dissertation title: Biological functions of a blue-green alga, Nostoc commune var. sphaeroides kutzing (N. commune).
  • Sarah Ehlers, MS in Nutrition, University of Nebraska-Lincoln, Completed in May 2008.
    Thesis title: Modulation of high-density lipoprotein metabolism in obesity-related insulin resistance.

Courses

  • NUSC 4236 Metabolism and Functions of Nutrients
  • NUSC 6313 Nutrition and Gene Expression
  • NUSC 5398-001 Special Topics: Inflammation, Diets and Chronic Disease
News and Updates

Fall 2016 Seminar Series
A Seminar Series Presented by the Department of Nutritional Sciences at the University of Connecticut
More Information

 

Scholarships

Please go to the CAHNR Scholarships and Financial Aid page for Scholarship information