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Ji-Young Lee, Ph.D., FAHA

Professor and Department Head

Office: 211C Advanced Technology Laboratory
TEL: 860-486-1827
E-mail: ji-young.lee@uconn.edu

EDUCATION

  • Ph.D. Nutrition, University of Nebraska-Lincoln
  • M.S. Nutritional Science and Dietetics, University of Nebraska-Lincoln
  • M.S. Food Chemistry, Kyung Hee University, Seoul, South Korea
  • B.S. Foods and Nutrition, Kyung Hee University, Seoul, South Korea

PROFESSIONAL EXPERIENCE

  • Department Head (January 2019 - ) Department of Nutritional Sciences, University of Connecticut, Storrs, CT
  • Professor (August 2017 - ) Department of Nutritional Sciences, University of Connecticut, Storrs, CT
  • Associate Professor (July 2010 – July 2017) Department of Nutritional Sciences, University of Connecticut, Storrs, CT
  • Member (October 2014 – Present)  Institute for Systems Genomics, University of Connecticut & The Jackson Laboratory
  • Assistant Professor (July 2005 – June 2010) Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE
  • Postdoctoral Fellow (June 2002 – June 2005) Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC

HONORS/AWARDS

  • International Scholar, Department of Food and Nutrition, Kyung Hee University, Seoul, South Korea, March 1, 2017 – present.
  • Fellow, American Heart Association, Arteriosclerosis, Thrombosis, and Vascular Biology Council, May 2013.
  • American Society for Nutrition, 1st Korean Nutrition Society Award, 2011.
  • Recognition of Junior Faculty for Excellence in Research, Agriculture Research Division, University of Nebraska-Lincoln, 2009.
  • Luella Selover Memorial Scholarship, 2001.
  • Widaman Trust Distinguished Graduate Assistant Award, 2000.
  • Undergraduate Scholarship, Kyung Hee University, Seoul, South Korea, 1989.

RESEARCH INTEREST

Dysregulation of energy metabolism, chronic inflammation and dyslipidemia are major contributors to the development of obesity-associated disease such as insulin resistance, non-alcoholic fatty liver disease, type 2 diabetes and cardiovascular disease. My research focuses on the identification of molecular mediators that are involved in lipid metabolism and inflammatory signaling pathways, and on the elucidation of molecular mechanisms by which dietary factors, such as blue-green algae, berries, phospholipids and astaxanthin, play regulatory roles in the integration of lipid metabolism and inflammation. The primary foci of my research program elegantly address a new concept of “immunometabolism” to link inflammatory signaling pathways to energy metabolism using state of the art molecular techniques and cell bioenergetics tools in various cells and animal models. In addition, another research focus lies on the identification of molecular targets that critically impact on the process of liver fibrosis with attempts to develop preventive and therapeutic strategies for liver fibrosis. In particular, how dietary factors regulate histone deacetylases as an epigenetic mode of action for the regulation of gene transcription in metabolic, inflammatory, and fibrogenic pathways are actively underway in my laboratory.

For more information on Dr. Lee's research, please visit https://sites.google.com/view/uconn-nutrition-lee-lab/home

PUBLICATIONS

  1. Y. Lee, T. X. Pham, M. Bae, S. Hu, E. O’Neill, O. K. Chun, M. J. Han, S. I. Koo, Y-.K. Park. J-.Y. Lee. Blackcurrant (Ribes nigrum) prevents obesity-induced non-alcoholic steatohepatitis in mice. Obesity 2019; 27:112-120.
  2. C. L. Miller, G. H. Norris, C. Jiang, J. Kry, A. Vitols, C. Carcia, Y-.K. Park. J-.Y. Lee, C. N. Blesso. Long-term supplementation of black elderberry improves HDL function, but promote hyperlipidemia with no effect on atherosclerosis development in apolipoprotein E-knockout mice. Mol Nutr Food Res 2018; 62: 1800404. Epub ahead of print on September 29, 2018.
  3. Q. Hu, M. Bae, E. Fleming, J-.Y. Lee, Y. Luo. Biocompatible polymeric nanoparitcles with exceptional gastrointestinal stability as oral delivery vehicles for lipophilic bioactives. Food Hydrocolloids 2018; 89:386-395.
  4. T. Wang, Q. Hu, J-.Y. Lee, Y. Luo. Solid lipid-polymer hybrid nanoparticles by in-situ conjugation for oral delivery of astaxanthin. J Agr Food Chem 2018; 66:9473-9480. Epub ahead of print on August 21, 2018.
  5. C. Farruggia, M-.B. Kim, M. Bae, Y. Lee, T. X. Pham, Y. Yang, M. J. Han, Y-.K. Park, J-.Y. Lee. Astaxanthin exerts anti-inflammatory and antioxidant properties in macrophages in NRF2-dependent and independent manners. J Nutr Biochem 2018; 62:202-209. Epub ahead of print on September 19, 2018.
  6. J. Wu, Y-.K. Park, M. Lin, J-.Y. Lee, L. Wang. Loss of PDK4 switches the hepatic NF-kB/TNF pathway from pro-survival to pro-apoptosis. Hepatology 2018; 68:1111-1124. Epub ahead of print on March 30, 2018.
  7. T. Wang, M. Bae, J-.Y. Lee, Y. Luo. Solid lipid-polymer hybrid nanoparticles prepared with natural biomaterials: A new platform for oral delivery of lipophilic bioactives. Food Hydrocolloids 2018; 84:581-592.
  8. T. X. Pham, M. Bae, Y. Lee, Y-.K. Park. J-.Y. Lee. Transcriptional and post-transcriptional repression of histone deacetylases by docosahexaenoic acid in macrophages. J Nutr Biochem 2018; 57:162-169. Epub ahead of print on March 10, 2018. (PMID: 29734115)
  9. M. Bae, Y-.K. Park, J-.Y. Lee. Food components with antifibrotic activity and implications in prevention of liver disease. J Nutr Biochem 2018; 55:1-11. Epub ahead of print on November 16, 2017. (PMID: 29268106)
  10. B. Kim, M. Bae, Y-.K. Park, H. Ma, T. Yuan, N. Seeram, J-.Y. Lee. Blackcurrant anthocyanins stimulated cholesterol transport via post-transcriptional induction of LDL receptor in Caco-2 cells. Eur J Nutr 2018; 57:405-415. Epub ahead of print on July 17, 2017. (PMID: 28718016)
  11. T.X. Pham, J-.Y. Lee. Epigenetic regulation of adipokines. Int J Mol Sci 2017; 18:1740; doi:10.3390/ijms18081740.
  12. T. X. Pham, Y-.K. Park, M. Bae, J-.Y. Lee. The potential role of an endotoxin-like mechanism for the anti-inflammatory effect of Spirulina platensis in macrophages: Insight into energy phenotype. J Med Food 2017; 20: 201-210. Epub ahead of print on January 25, 2017. (PMID: 28121488).
  13. B. Kim, C. Farruggia, C. S. Ku, T. X. Pham, Y. Yang, M. Bae, Casey J. Wegner, N. J. Farrell, E. Harness, Y-.K. Park, Sung I. Koo, J-.Y. Lee. Astaxanthin inhibited inflammation and fibrosis in the liver and adipose tissue of mouse models of diet-induced obesity and nonalcoholic steatohepatitis. J Nutr Biochem 2017; 43:27-35. Epub ahead of print on March 2, 2016. (PMID: 28193580)
  14. L. Xie, T. M. Vance, B. Kim, S. Lee, C. Caceres, Y. Wang, J-.Y. Lee, O. K. Chun, B. W. Bolling. Aronia berry polyphenol consumption reduces plasma total and low-density lipoprotein cholesterol in former smokers without lowering biomarkers of inflammation and oxidative stress: a randomized trial. Nutr Res 2017; 37:67-77. (PMID: 28215316)
  15. Y. Yang, M. Bae, Y-.K. Park, Y. Lee, T. X. Pham, S. Rudraiah, J. Manautou, S. I. Koo, J-.Y. Lee. Histone deacetylase 9 plays a role in the anti-fibrogenic effect of astaxanthin in hepatic stellate cells. J Nutr Biochem 2017; 40: 172-177. Epub ahead of print on Nov 12, 2016. (PMID: 27915160).
  16. S. M. Pillai, N. H. Sereda, M. L. Hoffman, E. V. Valley, T. D. Crenshaw, Y-.K. Park, J-.Y. Lee, S. A. Zinn, K. E. Govoni. The effect of poor maternal nutrition during gestation on bone development and mesenchymal stem cell activity in offspring. PlosOne 2016; 11:e0168382. (PMID: 27942040)
  17. B. Kim, S. Lee, Y-.K. Park, C. S. Ku, T. X. Pham, C. J. Wegner, Y. Yang, S. I. Koo, O. K. Chun, J-.Y. Lee. Blueberry, blackberry, and blackcurrant differentially affect plasma lipids and pro-inflammatory markers in diet-induced obesity mice. Nutr Res Pract 2016; 10:494-500. (PMID: 27698956). 
  18. T. X. Pham, Y-.K. Park, J-.Y. Lee. Anti-inflammatory effects of Spirulina platensis extract via the modulation of histone deacetylases. Nutrients 2016; 8:E381. Epub ahead of print on June 21, 2016. (PMID: 27338466).
  19. T.X. Pham, J-.Y. Lee. Anti-inflammatory effect of Spirulina platensis in macrophages is beneficial for adipocyte differentiation and maturation by inhibiting Nuclear factor-kB pathway in 3T3-L1 adipocytes. J Med Food 2016; 19:535-542. Epub ahead of print on May 20, 2016. (PMID: 27206252)
  20. S. Patel, A. Akalkotkar, J. J. Bivona III, J-.Y. Lee, Y-.K. Park, M. Yu, S. Colpitts, M. Vajdy. Vitamin A or E and a catechin synergize as vaccine adjuvant to enhance immune responses in mice through induction of early interleukin-15 but not interleukin-1b responses. Immunology 2016; 148:352-362. Epub ahead of print on May 2, 2016. (PMID: 27135790)
  21. M. Surendran-Nair, A. Kollanoor-Johny, S. Ananda-Baskaran, C. Norris, J-.Y. Lee, K. Venkitanarayanan. Selenium reduces enterohemorrhagic Escherichia coli O157:H7 verotoxin production and globotriaosylceramide receptor expression on host cells. Future Microbiol 2016; 11:745-756. Epub ahead of print on May 18, 2016. (PMID: 27191971)
  22. L. Xie, S. Lee, T. M. Vance, Y. Wang, B. Kim, J-.Y. Lee, O. K. Chun, B. W. Bolling. Bioavailability of anthocyanins and colonic polyphenol metabolites following consumption of aronia berry extract. Food Chem 2016; 211:860-868. (PMID: 27283706)    
  23. Y. Yang, M. Bae, B. Kim, Y-.K. Park, S. I. Koo, J-.Y. Lee. Astaxanthin prevents and reverses the activation of mouse primary hepatic stellate cells. J Nutr Biochem 2016; 29:21-26. Epub ahead of print on Nov 24, 2015. (PMID: 26895661)
  24. C. E. Dugan, D. Aguilar, Y-.K. Park, J-.Y. Lee, M-L. Fernandez. Dietary consumption lowers systemic inflammation and liver enzymes in typically low-dairy consumers with clinical characteristics of metabolic syndrome. J Am Coll Nutr 2016; 35:255-261. Epub ahead of print on Nov 23, 2015. (PMID: 26595359)
  25. G. Karim., K. Menzies, D. Ryu, C. J. Wegner, X. Wang, E. R. Ropelle, N. Moullan, H. Zhang, A. Perino, V. Lemos, B. Kim, Y-.K. Park, P. Alessandra, T. X. Pham, Y. Yang, C. S. Ku, S. I. Koo, A. Fomitchova, C. Canto, K. Schoonjans, A. A. Sauve, J-.Y. Lee*, J. Auwerx. Eliciting the mitochondrial unfolded protein response via NAD+ repletion prevents fatty liver disease. Hepatology 2016; 63:1190-1204. Epub ahead of print on Sept 25, 2015. (PMID: 26404765) * Shared corresponding authorship.
  26. S. Lee, B. Kim, S. D. Y, T. Vance, J.S Lee, J-.Y. Lee, S. I. Koo, D.O. Kim, M. H. Drissi, O. K. Chun. Relationship between oxidative stress and bone mass in obesity and effects of berry supplementation on bone remodeling in obese male mice: an exploratory study.  J Med Foods 2015; 18:476-482. Epub ahead of print on Sept 8, 2014. (PMID: 25198411)
  27. C. S. Ku, B. Kim, T. X. Pham, Y. Yang, Y-.K. Park, C. L. Weller, T. Carr, J-.Y. Lee. Hypolipidemic effect of a blue-green alga (Nostoc commune) is attributed to its nonlipid fraction by decreasing intestinal cholesterol absorption in C57BL/6J mice. J Med Food 2015; 18:1214-1222. Epub ahead of print on July 10, 2015. (PMID: 26161942)
  28. C. S. Ku, B. Kim, T. X. Pham, Y. Yang, C. J. Wegner, Y-.K. Park, M. Balunas, J-.Y. Lee. Blue-green algae inhibit the development of atherosclerotic lesions in apolipoprotein E knockout mice. J Med Food 2015; 18:1299-1306. Epub ahead of print on Nov 13, 2015. (PMID: 26566121)
  29. M-Y. Chung, E. Mah, C. Masterjohn, S. K. Noh, H. J. Park, R. M, Clark, Y-.K. Park, J-.Y. Lee, R. S. Bruno. Green tea lowers hepatic COX-2 and prostaglandin E2 in rats with dietary fat-induced nonalcoholic steatohepatitis. J Med Food 2015; 18:648-655. Epub ahead of print on Dec 2, 2014. (PMID: 25453513)  
  30. T. Benn, B. Kim, Y-.K. Park, Y. Yang, T. X. Pham, C.S. Ku, C. Farruggia, E. Harness J. A. Smyth, J-.Y. Lee. Polyphenol-rich blackcurrant extract exerts hypocholesterolemic and hypoglycemic effects in mice fed a diet containing high fat and cholesterol. Br J Nutr 2015: 113:1697-1703. (PMID: 25899149)
  31. Y. Yang, B. Kim, Y-.K. Park, S. I. Koo, J-.Y. Lee. Astaxanthin prevents transforming growth factor b1-induced pro-fibrogenic gene expression by inhibiting Smad3 activation in hepatic stellate cells. Biochimica Biophysica Acta 2015; 1850:178-185. (PMID: 25450180) 
  32. Y. Yang, T. X. Pham, C. J. Wegner, B. Kim, C. S. Ku, Y-.K. Park, J-.Y. Lee. Astaxanthin lowered plasma triglyceride and increased hepatic antioxidant gene expression in diet-induced obesity mice. Br J Nutr 2014; 112:1797-1804. (PMID: 25328157)
  33. T. Benn, B. Kim, Y-.K. Park, C. J. Wegner, E. Harness, T-G. Nam, D-O. Kim, J. S. Lee, J-.Y. Lee. Polyphenol-rich blackcurrant extract prevents inflammation in diet-induced obesity mice. J Nutr Biochem 2014; 25:1019-1025. (PMID: 25034502)
  34. W. Sittiwong, D. K. Zinnel, R. J. Fenton, D. Marshall, C. F. Story, B. Kim, J-.Y. Lee, R. Powers, R. G. Barletta, P. H. Dussault. Development of cyclobutene- and cyclobutane-functionalized fatty acids with inhibitory activity against Mycobacterium tuberoculosis. ChemMedChem 2014; 9:1838-1849. (PMID: 24902951)
  35. C. J. Andersen, J-.Y. Lee, C. N. Blesso, T. P. Carr, M-L. Fernandez. Egg intake during carbohydrate restriction alters peripheral blood mononuclear cell inflammation and cholesterol homeostasis in metabolic syndrome. Nutrients 2014; 6:2650-2667. (PMID: 25045936)
  36. Y. Yang, Y-.K. Park, B. Kim, J-.Y. Lee. Effects of long-term supplementation of blue-green algae on lipid metabolism in C57BL/6J mice. J Nutr Health and Food Sci 2014; 2:1-6. (PMID: 25614902)
  37. S. Lee, B. Kim, Y. Yang, T. X. Pham, Y-.K. Park, J. Manatou, S. I. Koo, O. K. Chun, J-.Y. Lee. Berry anthocyanins suppress the expression and secretin of pro-inflammatory mediators in macrophages by inhibiting nuclear translocation of NF-kB independent of NRF2-mediated mechanism. J Nutr Biochem 2014; 25:404-411. (PMID: 24565673)
  38. C. Masterjohn, Y-.K. Park, J-.Y. Lee, S. K. Noh, R. S. Bruno. Dietary fructose feeding increases adipose methylglyoxal accumulation in association with low expression and activity of glyoxalase-2. Nutrients 2013; 5:3311-3328. (PMID: 23966111)
  39. Y. Yang, B. Kim, J-.Y. Lee. Astaxanthin: structure, metabolism, and health benefits. J Hum Nutr Food Sci 2013; 1:1003 (1-11). 
  40. C. Masterjohn, E. Mah, Y-.K. Park, R. Pei, J-.Y. Lee, J. E. Manatou, R. S. Bruno. Acute glutathione depletion induces hepatic methylglyoxal accumulation by impairing its detoxification to D-lactate. Expt Biol Med 2013; 238:360-369. (PMID: 23760001)
  41. C. J. Andersen, C. N. Blesso, J-.Y. Lee, J. Barona, D. Shah, M. J. Thomas, M. L. Fernandez. Egg consumption during carbohydrate restriction modulates HDL lipid composition and increases the cholesterol-accepting capacity of serum in metabolic syndrome. Lipids 2013; 48:557-567. (PMID: 23494579)
  42. B. Kim, Y-.K. Park, C. J. Wegner, B. W. Bolling, J-.Y. Lee. Polyphenol-rich chokeberry extract regulates the expression of genes for lipogenesis and cholesterol transport in Caco-2 cells. J Nutr Biochem 2013; 24:1564-1570. (PMID: 23517916)
  43. B. Kim, C. S. Ku, T. X. Pham, Y-.K. Park, D. A. Martin, L. Xie, J-.Y. Lee, B. W. Bolling. Aronia melanocarpa (chokeberry) polyphenol rich extract improves antioxidant function and reduces total plasma cholesterol in apolipoprotein E knockout mice. Nutr Res 2013; 33:406-413. (PMID: 23684442)
  44. C. S. Ku, Y. Yang, Y-.K. Park, J-.Y. Lee. Health Benefits of blue-green algae: Prevention of cardiovascular disease and nonalcoholic fatty liver disease. J Med Food 2013; 16:103-111. (PMID: 23402636)
  45. C. S. Ku, T. X. Pham, Y-.K. Park, B. Kim, M. Shin, I. Kang, J-.Y. Lee. Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-kB pathway in macrophages and splenocytes. Biochimica Biophysica Acta 2013; 1830:2981-2988. (PMID: 23357040)
  46. C. J. Wegner, B. Kim, J-.Y. Lee. Trust your gut: Galvanizing nutritional interest in intestinal cholesterol metabolism for protection against cardiovascular diseases. Nutrients 2013; 5: 208-222. (PMID: 23325147)
  47. T. X. Pham, J-.Y. Lee. Dietary regulation of histone acetylase and deacetylase for the prevention of metabolic diseases. Nutrients 2012; 4:1868-1886. (PMID: 23363995)
  48. J. Barona, C. N. Blesso, C. J. Andersen, Y-.K. Park, J-.Y. Lee, M-L. Fernandez. Grape consumption increases anti-inflammatory markers and upregulates peripheral nitric oxide synthase in the absence of dyslipidemias in men with metabolic syndrome. Nutrients 2012; 4:1945-1957. (PMID: 23222963)  
  49. Y-.K. Park, T. X. Pham, J-.Y. Lee. Lipopolysaccharide represses the expression of ATP-binding cassette transporter G1 and scavenger receptor class B, type I in murine macrophages. Inflamm Res 2012; 61:465-472. (PMID: 22240665)
  50. C. S. Ku, Y-.K. Park, S. L. Coleman, J-.Y. Lee. Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages. J Nutr Biochem 2012; 23: 1271-1276. (PMID: 22209005)
  51. J-.Y. Lee, Y-.K. Park, S. I. Koo. ATP binding cassette transporter A-I and HDL metabolism: Effects of fatty acids. J Nutr Biochem 2012; 23:1-7. (PMID: 21684139)
  52. J. E. Kim, R. M. Clark, Y-.K. Park, J-.Y. Lee, M. L. Fernandez. Lutein decreases oxidative stress and inflammation in liver and eyes of guinea pigs fed a hypercholesterolemic diet. Nutr Res Pract 2012; 6:113-119. (PMID: 22586499)
  53. H. J. Park, J-.Y. Lee, M.Y. Chung, Y-.K. Park, A. Bower, S. I. Koo, C. Giardina, R. S. Bruno. Green tea extract suppressed NFkB activation and inflammatory responses in a diet-induced obese rats with nonalcoholic steatohepatitis. J Nutr 2012; 142:57-63. (PMID: 22157544)
  54. J. J. Jones, Y-.K. Park, J-.Y. Lee, R. H. Lerman, M. L. Fernandez. A Mediterranean-style, low-glycemic-load, diet reduces the expression of HMG-CoA reductase in mononuclear cells and correlated with decreases in insulin in women with metabolic syndromes. Nutr Res 2011; 31:659-664. (PMID: 22024489)
  55. Y. Yang, J. M. Seo, A. Nguyen, T. X. Pham, H. J. Park, Y-.K. Park, R. S. Bruno, J-.Y. Lee. Astaxanthin from Haematococcus pluvialis lowered plasma lipid concentrations and increased antioxidant defense in apolipoprotein E knockout mice. J Nutr 2011; 141:1611-1617. (PMID: 21734060)
  56. S. L. Coleman, Y-.K. Park, J-.Y. Lee. Unsaturated fatty acids repress the expression of adipocyte fatty acid binding protein via the modulation of histone deacetylation in RAW 264.7 macrophages. Eur J Nutr 2011; 50:323-330. (PMID: 21046125) 
  57. J. M. Seo, J-.Y. Lee, G. E. Ji, J. C. You. Down-regulation of ATP-binding cassette transporter G1 expression by unmethylayed CpG oligodeoxynucleotides (CpG ODNs) in RAW 264.7 macrophages. Expt Mol Med 2011; 43:510-516. (PMID: 21737995)
  58. S. J. Ehlers, S. M. Larson, H. E. Rasmussen, Y-.K. Park, J-.Y. Lee.  High-density lipoprotein metabolism in human apolipoprotein B transgenic/brown adipose tissue deficient mice, a model of obesity-induced hyperinsulinemia. Appl Physiol Nutr Metab 2011; 36:313-322. (PMID: 21574779) 
  59. Y. Yang, Y-.K. Park, J-.Y. Lee. In vitro and in vivo safety assessment of edible blue green algae, Nostoc commune var. sphaeroides Kützing and Spirulina plantensis. Food Chem Toxicol 2011; 49:1560-1564. (PMID: 21473896) 
  60. C. S. Ku, H. E. Rasmussen, Y-.K. Park, E. D. Jesch, J-.Y. Lee. Unsaturated fatty acids repress the expression of ATP-binding cassette transporter A1 in HepG2 and FHs 74 Int cells. Nutr Res 2011; 31:278-285. (PMID: 21530801)   
  61. H. J. Park, D. A. DiNatale, M-Y. Chung, Y-.K. Park, J-.Y. Lee, S. I. Koo, M. O’Connor, J. E. Manautou, R. S. Bruno. Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice. J Nutr Biochem 2011; 22:151-159. (PMID: 20655714)
  62. V. L. Schlegel, R. Zbasnik, B. H. Lee, T. P. Carr, J-.Y. Lee, C. L. Weller, S. L. Cuppett. Characterization of potential health promoting lipids in the co-products of de-flossed milkweed. J Food Chemistry 2010; 126:15-20.
  63. E. D. Jesch, J. M. Seo, T. P. Carr, J-.Y. Lee. Sitosterol reduces mRNA and protein expression levels of Niemann-Pick C1-Like 1 (NPC1L1) in FHs 74 Int cells. Nutr Res 2009; 29: 859-866. (PMID: 19963159)
  64. J. T. Hoi, C. L. Weller, V. L. Schlegel, S. L. Cuppet, J-.Y. Lee, T. P. Carr. Sorghum distillers dried grain lipid extract increases cholesterol excretion and decreases plasma and liver cholesterol concentration in hamsters. J Funct Food 2009; 1: 381-386.
  65. H. E. Rasmussen, I. Martinez, J-.Y. Lee, J. Walter. Alteration of the murine gastrointestinal microbiota by edible blue-green algae.  J Appl Microbiol 2009; 107: 1108-1118. (PMID: 19486425) 
  66. H. E. Rasmussen, K. R. Blobaum, E. D. Jesch, C. S. Ku, Y-.K. Park, F. Lu, T. P. Carr, J-.Y. Lee. Hypocholesterolemic effect of Nostoc commune var sphaeroides Kützing, an edible blue-green alga.  Eur J Nutr 2009; 48:387-394. (PMID: 19404563)
  67. S. Shrestha, S. J. Ehlers, J-.Y. Lee, M-L. Fernandez, S. I. Koo.  Dietary green tea extract lowers plasma and hepatic triglyceride and decreases the expression of SREBP-1c mRNA and its responsive genes in fructose-fed ovariectomized rats.  J Nutr 2009; 139:640-645. (PMID: 19193814)
  68. A. Mulya, J-.Y. Lee, A. K. Gebre, E. Y. Boudyguina, S-K. Chung, T. L. Smith, P. L. Colvin, X. C. Jiang, J. S. Parks.  Initial Interaction of ApoA-I with ATP Binding Cassette Transporter A1 (ABCA1) Impacts in vivo metabolic fate of nascent HDL.  J Lipid Res 2008; 49:2390-2401. (PMID: 18583707)
  69. X. Zhu, J-.Y. Lee, J. M. Timmins, J. M. Brown, E. Y. Boudyguina, A. Mulya, A. K. Gebre, M. C. Willingham, E. M. Hiltbold, N. Mishra, N. Maeda, J. S. Parks.  Increased cellular free cholesterol in macrophage-specific Abca1 knockout mice enhances pro-inflammatory response of macrophages.  J Biol Chem 2008; 283:22930-22941. (PMID: 18552351)
  70. H. E. Rasmussen, K. R. Blobaum, Y-.K. Park, S. J. Ehlers, F. Lu, J-.Y. Lee.  Lipid extract of Nostoc commune var. sphaeroides Kützing, a blue-green alga, inhibits the activation of sterol regulatory element binding proteins in HepG2 cells.  J Nutr 2008; 138:476-481. (PMID: 18287352)
  71. Y-.K. Park, H. E. Rasmussen, S. J. Ehlers, K. R. Blobaum, F. Lu, V. L. Schlegal, T. P. Carr, J-.Y. Lee.  Repression of proinflammatory gene expression by lipid extract of Nostoc commune var sphaeroides Kützing, a blue-green alga, via inhibition of nuclear factor-κB in RAW 264.7 macrophages.  Nutr Res 2008; 28:83-91. (PMID: 19083393)
  72. Young-Nam Kim, J-.Y. Lee, J. A. Driskell. Marginal folate inadequacy observed in a group of young children in Kwangju, Korea.  Nutr Res and Practice 2007; 2:120-125. (PMID: 20535397)
  73. A. Mulya, J-.Y. Lee, A. K. Gebre, M. Thomas, P. L. Colvin, J. S. Parks.  Minimal lipidation of pre-b HDL by ABCA1 results in reduced activity to interact with ABCA1. Arterio Thromb Vasc Biol 2007; 27:1828-1836. (PMID: 17510466)
  74. J-.Y. Lee, R. Badeau, A. Mulya, E. Boudyguina, A. K. Gebre, T. L. Smith, J. S. Parks. Functional lecithin:cholesterol acyltransferase (LCAT) deficiency in human apolipoprotein A-I transgenic scavenger receptor class B, type I knockout mice. J Lipid Res 2007; 48:1052-1061. (PMID: 17272829)
  75. J-.Y. Lee, J. M. Timmins, A. Mulya, T. L. Smith, Y. Zhu, E. M. Rubin, P. L. Colvin, J. S. Parks.  Plasma HDL in human apoA-I transgenic-Abca1 knockout mice undergo normal intravascular remodeling but are hypercatabolized by the kidney. J Lipid Res 2005; 46:2233-2245. (PMID: 16024913)  
  76. J. M. Timmins, J-.Y. Lee, E. Boudyguina, K. Kluckman, L. R. Brunham, A. Mulya, A. K. Gebre, J. Coutinho, P. L. Colvin, T. L. Smith, M. R. Hayden, N. Maeda, J. S. Parks. Targeted inactivation of hepatic ABCA1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apolipoprotein A-I. J Clin Invest 2005; 115:1333-1342. (PMID: 15841208)
  77. J-.Y. Lee, T. P. Carr. Dietary fatty acids regulate the expression of ABCA5 and ABCG8 in hamsters. Nutr Res 2005; 25:167-175.
  78. J-.Y. Lee, J. S. Parks. ATP-binding cassette AI (ABCA1) and its role in HDL formation. Curr Opin Lipidol 2005; 16:19-25. (PMID: 15650559)
  79. J-.Y. Lee, T. P. Carr. Dietary fatty acids regulate acyl-CoA:cholesterol acyltransferase and cytosolic cholesteryl ester hydrolase in hamsters. J Nutr 2004; 134:3239-3244. (PMID: 15570019)
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  81. J-.Y. Lee, N. M. Lewis, S. E. Scheideler, T. P. Carr. Consumption of omega-3 fatty acid-enriched eggs and serum lipids in humans. J Nutraceuticals Funct Med Foods 2003; 4:3-13.
  82. R. L. Cowles, J-.Y. Lee, D. D. Gallaher, C. L. Stuefer-Powell, T. P. Carr. Dietary stearic acid alters gallbladder bile acid composition in hamsters fed cereal-based diets. J Nutr 2002; 132:3119-3122. (PMID: 12368404)
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GRANTS (last 5 years)
 
  • National Institute of Health (R01) 1R01DK108254-01, “Nutritional transcriptomics approach for the role of astaxanthin in liver fibrosis”, 9/25/2015-8/31/2019. Role in project:  Principal Investigator
  • United States Department of Agriculture, AFRI Grant 2016-67017-24463, “Protective action of blackcurrant against obesity-associated inflammation: Linking macrophage plasticity to energy metabolism”, 12/01/2015-11/30/2018. Role in project: Principal Investigator
  • National Institute of Health (R15) 1R15AT00861001, “Metabolites from edible blue-green algae for obesity-induced inflammation”, 12/15/2014-12/14/2017. Role in project:  Co-investigator
  • Nutricia Research Foundation Research Grant, “Mechanistic understanding of the effect of cranberries on HDL metabolism”, 2/01/2015-1/31/2018. Role in project: Principal Investigator
  • United States Department of Agriculture, Hatch CONS00972, “Role of bioactive components in hepatic stellate cell activation”, 10/01/2016-9/30/2021. Role in project: Principal Investigator
  • United States Department of Agriculture, AFRI Postdoctoral Fellowship, “A novel role of Spirulina in the regulation of macrophage phenotype for the prevention of NASH”, 1/15/2017-1/14/2019. Role in project: Mentor 
  • United States Department of Agriculture, Multi-state Hatch, CONS00916, “W-3002, Nutrient Bioavailability—Phytonutrients and Beyond”, 10/01/2013-9/30/2018. Role in project: Principal Investigator
  • United States Department of Agriculture, AFRI Seed Grant, 2016-08864, “Anti-fibrogenic action of astaxanthin in adipose tissue: A mechanism to inhibit obesity-associated inflammation”, 4/01/2017-3/31/2019. Role in project: Co-investigator 
  • United States Department of Agriculture, AFRI, “Enhanced stability and bioavailability of astaxanthin encapsulated in multilayer-coated lipid particles”, 3/01/2017-2/28/2019. Role in project: Co-program director
  • Dairy Management Inc., “Milk phospholipids for the prevention of atherosclerosise”, 3/01/2017-2/28/2019. Role in project: Co-investigator 
  • Egg Nutrition Center, “Pilot study for evaluating the effect of egg phospholipids on the modulation of cholesterol homeostasis”, 7/01/2015-6/30/2017.  Role in project: Principal Investigator
  • United States Department of Agriculture, Hatch CONS00872, “Transcriptional regulation of fatty acid binding protein 4 by dietary fatty acids in macrophages”, 10/01/2011-9/30/2016. Role in project: Principal Investigator
  • United States Department of Agriculture, AFRI Seed Grant, CONS2014-06619, “Black elderberry as a novel functional food: Protection from HDL dysfunction in chronic inflammation”, 2/1/2015-1/31/2017. Role in project: Co-Investigator
  • University of Connecticut Scholarship Facilitation Fund, “Regulation of adipose tissue fibrosis by astaxanthin”, 1/01/2016-12/31/2016. Role in project:  Principal Investigator
  • University of Connecticut Research Excellence Program, “Gene therapy for the prevention of liver fibrosis”, 3/15/2015-3/14/2016. Role in project:  Principal Investigator
  • United States Department of Agriculture, AFRI (2012-67018-19290), “Bioactivity of astaxanthin in the prevention of hepatic inflammation”, 02/01/2012-01/31/2016. Role in project: Principal Investigator
  • United States Department of Agriculture, AFRI Equipment Grant, CONS 2013-03483. “Use of a cell bioenergetics analyser to determine the effect of diet and bioactive food components on energy metabolism”, 12/01/2013-11/30/2015. Role in project: Principal Investigator
  • United States Department of Agriculture, AFRI Predoctoral Fellowship 2014-01870, “Bioactivity of Spirulina platensis in the prevention of obesity-associated inflammation and insulin resistance by the modulation of histone deacetylases”, 1/01/2015-12/31/2015. Role in project: Mentor
  • National Institute of Health (R21AT005152), “Evaluation of athero-protective role of blue-green algae”, 09/30/2009-08/31/2013. Role in project:  Principal Investigator
  • State of Connecticut Department of Public Health, “The effect of chokeberry polyphenols on biomarkers of cardiovascular disease and antioxidant defense in former smokers”, 08/01/2012-5/31/2015. Role in project: Co-PI
  • Fuji Chemical Industry Co., “Role of astaxanthin in the prevention of hepatic stellate cell activation”, 07/01/2013-07/31/2014. Role in project: Principal Investigator
  • University of Connecticut College of Agriculture and Natural Resources Equipment Competition, “Li-Cor Odyssey CLx Infrared Imaging System”, September 2012. Role in project:  Principal Investigator
  • United States Department of Agriculture, Hatch CONS0080, “Efficacy of chokeberry polyphenols to reduce oxidative stress and atherosclerosis in the ApoE knockout mouse”, 10/01/2011-9/30/2016. Role in project: Co-investigator
  • United States Department of Agriculture, Multi-state Hatch, CONS00891, “N-3 polyunsaturated fatty acids and human health and disease”, 10/01/2012-9/30/2013. Role in project: Principal Investigator
  • Nutricia Research Foundation Research Grant, “Chokeberry polyphenols promote bone health by inhibiting inflammation-induced bone resorption”, 1/01/2013-12/31/2014. Role in project: Collaborator
  • Connecticut Innovations, Advanced Technology Phase I STTR, “A novel vaccine against vaginal transmission of Chlamydia trachomatis”, 05/01/2014-11/30/2014. Role in project:  UCONN Investigator
  • United States Department of Agriculture, Multi-state Hatch, CONS00916, “Nutrient Bioavailability-Phytonutrients and Beyond”, 10/01/2012-9/30/2013. Role in project: Principal Investigator
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