skip to content
 

Bradley Bolling, PhD

Assistant Professor

Phone: (860)-486-2180
Email: bradley.bolling@uconn.edu

Education and Training

  • Postdoctoral Fellow, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Antioxidants Research Laboratory, in the Training in Education and Critical Research Skills (TEACRS Program, an NIH Institutional Research and Career Development Award (IRACDA) Training Grant. 2007-2010.
  • Ph.D., University of Wisconsin-Madison, Food Science.  2007.
  • University of Wisconsin-Madison Delta Program, Certificate in teaching and learning. 2007.
  • B.S., University of Wisconsin-Madison, Food Science, Honors in Research. 2002.

Professional Experience

  • Assistant Professor, University of Connecticut, Dept. of Nutritional Sciences 2010-present.
  • Postdoctoral Fellow, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Antioxidants Research Laboratory. 2007-2010.
  • Adjunct Faculty, University of Massachusetts, Boston. Fall, 2009.
  • Graduate Research Assistant, Department of Food Science, University of Wisconsin-Madison.  2002-2007.

Honors and Awards

  • Hamish Munro Postdoctoral Excellence Award, HNRCA at Tufts University. 2009.
  • American Society for Nutrition (ASN) Dietary Bioactives Postdoctoral Poster Competition, 1st Place, Experimental Biology, New Orleans. 2009.
  • Institute of Food Technologists Student Association (IFTSA) Product Development Competition, 1st Place Team, IFT Annual Meeting. 2005.
  • American Oil Chemists Society Health and Nutrition Division Student Excellence Award. 2005
  • American Oil Chemists Society Honored Student Award. 2005.
  • American Oil Chemists Society Natural Health Research Institute Scholarship for Nutrition and Cancer Prevention or Treatment. 2004-2005.
  • Food Chemistry Division Paper Competition, 2nd Place, IFT Annual Meeting. 2003.
  • Donald A. Withycombe Fellowship, American Chemical Society, Food Chemistry Division. 2003.
  • Institute of Food Technologists (IFT) Graduate Fellowship. 2003.
  • Hilldale Undergraduate Research Fellowship. 2002.
  • Wisconsin Academic Achievement Scholarship.1998-2002.

Professional Affiliations

  • American Chemical Society
  • American Society for Nutrition
  • Institute of Food Technologists
  • International Society for Nutraceuticals and Functional Foods

Courses Taught

Undergraduate

  • NUSC 1165 Fundamentals of Nutrition
  • NUSC 4295 Dietary Supplements and Nutraceuticals
  • NUSC 4237W Writing in the Nutrition Field

Graduate

  • NUSC 5394 Graduate Seminar
  • NUSC 5398 Phytochemicals in Human Health and Disease

Publications

  • Xie, L, Bolling, B. UHPLC-MS characterization of stilbenes in California almonds (Prunus dulcis). Food Chemistry, 2014;148:300-306.
  • Taheri, R, Connoly, B, Brand, M, Bolling, B. Underutilized chokeberry (Aronia melanocarpa, arbutifolia, prunifolia) are rich sources of anthocyanins, flavonoids, hydroxycinnamic acids, and proanthocyanidins. Journal of Agricultural and Food Chemistry, 2013;61:8581-8588.
  • Bolling, B, Chen, Y-Y, Chen, C-Y. Contributions of polyphenols and vitamin C to the antioxidant capacity of pomegranate and grape juices: synergism and antagonism among components. International Journal of Food Science and Technology, 2013;48:2650-2658.
  • Kim, B,  Park, Y, Bolling, B, Lee, J. Polyphenol-rich Aronia melanocarpa (chokeberry) extract regulates expression of cholesterol and lipid metabolism genes in Caco-2 cells. Journal of Nutritional Biochemistry, 2013;24:1564-1570.
  • Kim, B, Ku, CS, Pham, TX, Park, Y, Martin, DA, Xie, L, Taheri, R, Lee, J, Bolling, B. Aronia melanocarpa (chokeberry) polyphenol rich extract improves antioxidant function and reduces total plasma cholesterol in apolipoprotein E knockout mice. Nutrition Research, 2013;33:406-13.
  • Blesso CN, Andersen CJ, Bolling B, Fernandez ML. Egg intake improves carotenoid status by increasing plasma HDL cholesterol in adults with metabolic syndrome. Food and Function. 2013;4:213-21.
  • Xie, L., Roto, AV., Bolling, B. Characterization of ellagitannins, gallotannins and bound proanthocyanidins from California almond (Prunus dulcis) varieties. Journal of Agriculture and Food Chemistry. 2012;60:12151-6.
  • Andarwulan, N., Kurniasih, D., Apriady, R., Rahmat, H., Roto, A., and Bolling, B. Polyphenols, carotenoids, and ascorbic acid in underutilized medicinal vegetables. Journal of Functional Foods. 2012;4:339-47.
  • Bolling, B. Chen, Y-Y., Kamil, A., Chen, C-Y. Assay dilution factors confound measures of total antioxidant capacity in polyphenol-rich juices. Journal of Food Science. 2012;77:H69-H75
  • Bolling, B., Ji, L., Lee, C.H., Parkin, K. Dietary supplementation of ferulic acid and ferulic acid ethyl ester induces quinone reductase and glutathione-S-transferase in rats. Food Chemistry. 2011;124:1-.
  • Bolling, B., Court, M. H., Blumberg, J., Chen, C-Y. Oliver. Microsomal quercetin glucuronidation in rat small intestine depends on age and segment. Drug Metabolism and Disposition. 2011;39:1406-14
  • Bolling, B., Chen, O., McKay, D., Blumberg, J. Tree Nut Phytochemicals: Composition, Antioxidant Capacity, Bioactivity, Impact Factors. A Systematic Review of Almonds, Brazils, Cashews, Hazelnuts, Macadamias, Pecans, Pine Nuts, Pistachios, and Walnuts. Nutrition Research Reviews. 2011;24:244-75.
  • Bolling, B., McKay, D, Blumberg, J. The phytochemical composition and antioxidant actions of tree nuts. Asia Pacific Journal of Clinical Nutrition.2010;19:117-23.
  • Bolling, B., Court, M. H., Blumberg, J., Chen, C-Y. Oliver. The kinetic basis for age-associated changes in quercetin and genistein glucuronidation by rat liver microsomes, Journal of Nutritional Biochemistry. 2010;21:498-503
  • Andarwulan, N., Batari, R. Sandrasari, D. A., Bolling, B., Wijaya, H. Flavonoid content and antioxidant activity of vegetables from Indonesia.  Food Chemistry. 2010;121:1231-5.
  • Bolling, B., Dolnikowski, G., Blumberg, J., Chen, C-Y. Oliver. Polyphenol content and antioxidant activity of California almonds depend on cultivar and harvest year. Food Chemistry. 2010;122:819-25.
  • Bolling, B., Blumberg, J., Chen, C-Y. Oliver. The influence of roasting, pasteurization, and storage on the polyphenol content and antioxidant capacity of California almond skins. Food Chemistry. 2010;123:1040-47.
  • Bolling, B., Parkin, K. Limited contribution of isoflavones to hepatocellular phase II enzyme-inducing activity of soybean (Glycine max) extracts. Food Chemistry. 2009;113:1069-75
  • Bolling, B., Dolnikowski, G., Blumberg, J., Chen, C-Y. Oliver. Quantification of almond skin polyphenols by liquid chromatography-mass spectrometry. Journal of Food Science. 2009;74:C326-32.
  • Bolling, B., Blumberg, J., Chen, C-Y. Oliver. Extraction methods determine the antioxidant capacity and induction of quinone reductase by soy products in vitro. Food Chemistry. 2009;116:351-5
  • Bolling, B., Chen, C-Y., Blumberg, J.  Tea and health: Preventive and therapeutic usefulness in the elderly? Current Opinion in Clinical Nutrition and Metabolic Care. 2009;12:42-8.
  • Bolling, B., Parkin, K. Phenolic derivatives from soy flour ethanol extract are potent in vitro quinone reductase (QR) inducing agents. Journal of Agricultural and Food Chemistry. 2008;56:10473-80.
  • Bolling, B., Chen, E., Parkin, K.  Quinone reductase inducing and antioxidant activities of aqueous isolates of green bean (Phaseolus vulgaris L.).  Food Research International. 2007;40:182-90.
  • Lee, C-H, Wettasinghe, M, Bolling, B., Ji, L., Parkin, K.  Betalains, phase II enzyme-inducing components from red beetroot (Beta vulgaris L.) extracts. Nutrition and Cancer. 2005;53:91-103.
  • Wettasinghe, M., Bolling, B., Plhak, L., Xiao, H., Parkin, K.  Phase II enzyme-inducing and antioxidant activities of beetroot (Beta vulgaris L.) extracts from phenotypes of different pigmentation. Journal of Agricultural and Food Chemistry. 2002;50:6704-9.
  • Wettasinghe, M., Bolling, B., Plhak, L., Parkin, K.  Screening for phase II enzyme-inducing and antioxidant activities of common vegetables. Journal of Food Science. 2002;67:2583-8.
  • Bolling, B., Schmidt, D.J., Ingham, S.C.  Development of a simple method for detecting presumptive Escherichia coli on fresh retail beef. Journal of Food Science. 2002;67:258-61.

Recent Presentations

Oral

  • Bolling, B. Bioactivity of aronia berries: should extracts be standardized to anthocyanins? 7th International Symposium of Ayurveda and Health, Farmington, CT. Oct 18-20, 2013.
  • Martin D, Taheri R, Brand M, Draghi II A, Sylvester F, Bolling B. Polyphenol-rich red and purple aronia berry extracts inhibit interleukin-6 from mouse splenocytes. Experimental Biology, Boston, MA, April 20-23, 2013. FASEB J (2013). 27:348.3.
  • Bolling, B. Identification of hydrolysable tannins, bound proanthocyanidins, and stilbenes in California almonds. 2012 International Society for Nutraceuticals and Functional Foods Annual Conference, Kona, HI, Dec 2-6, 2012.
  • Kim, B., Park, Y., Taheri, R., Kimball, K., Roto, A., Lee, J., and Bolling, B. Polyphenol-rich Aronia melanocarpa (chokeberry) extract regulates expression of cholesterol and lipid metabolism genes in Caco-2 cells. The FASEB Journa (2012). 26, 251.252. Experimental Biology, San Diego CA, April 21-25, 2012.
  • Bolling, B., Court, M., Blumberg, J., Chen, C-Y. Age-related changes in quercetin glucuronidation by rat intestine microsomes are correlated with UGT1a1 protein expression. The FASEB Journal (2011). 25, 234.6 Experimental Biology, Washington DC, April 9-13, 2011.
  • Bolling, B. The influence of cultivar, harvest year, roasting, pasteurization, and storage conditions on polyphenol content and antioxidant capacity of California almond skins. American Chemical Society 241st Annual Meeting, Anaheim CA, March 29-31st, 2011.
  • Bolling, B., Blumberg, J. B., Chen, C.-Y. O The influence of cultivar, harvest year, roasting, pasteurization, and storage conditions on polyphenol content and antioxidant capacity of California almond skins. International Society for Nutraceuticals and Functional Foods Annual Conference. Bali, Indonesia, Oct 11-15, 2010. 

Poster

  • Blesso CN, Andersen CJ, Bolling B, Fernandez ML. Increases in plasma lutein and zeaxanthin by egg intake is associated with the formation of larger HDL particles in participants with metabolic syndrome. Experimental Biology, Boston, MA, April 20-23, 2013. FASEB J April 9, 2013 27:638.16.
  • Taheri R, Durocher S, Brand M, Bolling, B. Impact of harvest timing on the polyphenol content of black chokeberry (Aronia melanocarpa, cv ‘Viking’) juice. Experimental Biology, Boston, MA, April 20-23, 2013. FASEB J April 9, 2013 27:lb272.
  • Xie L, Bolling B. Identification of resveratrol-3-β-glucoside in California almond varieties. Experimental Biology, Boston, MA, April 20-23, 2013. FASEB J April 9, 2013 27:1079.25.
  • Bolling B, Roto A, Kimball K, Xie L. Extractable and non-extractable proanthocyanidins of nonpareil, carmel, and butte california almonds. The FASEB Journal. (2012) 26:1025.6. Experimental Biology, San Diego CA, April 21-25, 2012.
  • Kim, B., Ku, C. S., Pham, T., Park, Y., Martin, D., Xie, L., Taheri, R., Lee, J., and Bolling, B. Aronia melanocarpa (chokeberry) polyphenol rich extract reduces plasma cholesterol and improves antioxidant function in Apolipoprotien E knockout mice. The FASEB Journal. (2012). 26, 1026.1029. Experimental Biology, San Diego CA, April 21-25, 2012.
  • Blumberg, J., Chen, C.-Y. O., McKay, D., Bolling, B. Nutrient Databank values for the polyphenols and related phytochemicals of tree nuts. 5th International Conference on Polyphenols and Health. Barcelona, Spain, Oct 17-20, 2011.
  • Bolling, B., Chen, C.-Y. O., McKay, D., Blumberg, J. Nutrient Databank values for the phytochemical and antioxidant content of tree nuts. 35th National Nutrient Databank Conference. Bethesda, MD, Apr. 8, 2011.

Current Research Support

Reduction of obesity-associated intestinal inflammation by low-fat dairy yogurt, Dairy Research Institute.
Collaborators: Richard Bruno, Ohio State University (Co-PI)

The effect of chokeberry polyphenols on biomarkers of cardiovascular disease and antioxidant defenses in former smokers, Connecticut Department of Public Health.
Collaborators: Ock Chun, Nutritional Sciences (Co-PI); Ji-Young Lee, Nutritional Sciences

Efficacy of Aronia (chokeberry) polyphenols to inhibit Th17 in vitro and in a mouse model of inflammatory bowel diseases (IBD), University of Connecticut Diet and Health Initiative Competition
Collaborators: Mark Brand, Horticulture; Fransisco Sylvester and Anthony Vella, Immunology, UConn Health Center

Efficacy of chokeberry polyphenols to reduce oxidative stress and atherosclerosis in the
ApoE knockout mouse, USDA Hatch Funds           

(Co-I) Toward realizing the promised mental health benefits of poorly-soluble food components by enhancing by enhancing their oral absorption- using curcumin as a model compound, University of Connecticut Diet and Health Initiative Competition, Co-Investigator
Collaborators: Robin Bogner (PI) School of Pharmacy, Lisa Conti UCHC, Jayesh Kamath UCHC.

News and Updates

Fall 2014 Seminar Series
A Seminar Series Presented by the Department of Nutritional Sciences at the University of Connecticut
More Information

 

Scholarships

Please go to the CANR Scholarships and Financial Aid page for Scholarship information