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Bradley Bolling, PhD

Assistant Professor

Phone: (860)-486-2180
Email: bradley.bolling@uconn.edu

Education and Training

  • Postdoctoral Fellow, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Antioxidants Research Laboratory, in the Training in Education and Critical Research Skills (TEACRS Program, an NIH Institutional Research and Career Development Award (IRACDA) Training Grant. 2007-2010.
  • Ph.D., University of Wisconsin-Madison, Food Science.  2007.
  • University of Wisconsin-Madison Delta Program, Certificate in teaching and learning. 2007.
  • B.S., University of Wisconsin-Madison, Food Science, Honors in Research. 2002.

Professional Experience

  • Postdoctoral Fellow, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Antioxidants Research Laboratory. 2007-2010.
  • Adjunct Faculty, University of Massachusetts, Boston. Fall, 2009.
  • Graduate Research Assistant, Department of Food Science, University of Wisconsin-Madison.  2002-2007.
  • Teaching Assistant, Department of Food Science, University of Wisconsin-Madison. 2004-2005.
  • Undergraduate Research Assistant, Department of Food Science, University of Wisconsin-Madison. 2000-2002.

Honors and Awards

  • Hamish Munro Postdoctoral Excellence Award, HNRCA at Tufts University. 2009.
  • American Society for Nutrition (ASN) Dietary Bioactives Postdoctoral Poster Competition, 1st Place, Experimental Biology, New Orleans. 2009.
  • Institute of Food Technologists Student Association (IFTSA) Product Development Competition, 1st Place Team, IFT Annual Meeting. 2005.
  • American Oil Chemists Society Health and Nutrition Division Student Excellence Award. 2005
  • American Oil Chemists Society Honored Student Award. 2005.
  • American Oil Chemists Society Natural Health Research Institute Scholarship for Nutrition and Cancer Prevention or Treatment. 2004-2005.
  • Food Chemistry Division Paper Competition, 2nd Place, IFT Annual Meeting. 2003.
  • Donald A. Withycombe Fellowship, American Chemical Society, Food Chemistry Division. 2003.
  • Institute of Food Technologists (IFT) Graduate Fellowship. 2003.
  • Hilldale Undergraduate Research Fellowship. 2002.
  • Wisconsin Academic Achievement Scholarship.1998-2002.

Professional Affiliations

  • American Society for Nutrition, 2007-present.
  • American Chemical Society, 2002-present.
  • Institute of Food Technologists, 2001-present.

Research Interests

Chronic diseases account for 70% of all deaths in the United States. Lifestyle and diet have the potential to reduce the risk and complications of chronic disease. For example, it is estimated that lifestyle and diet changes can reduce chronic disease risk by 80%. However, incomplete knowledge regarding abundance, metabolism, and bioactivity of food components has limited dietary recommendations for chronic disease prevention. Our group has been working to answer the following questions to fill these knowledge gaps:

What is the polyphenol content of food supply?
What bioactive agents are most promising for disease prevention?
What is the role of intestinal health in chronic disease?

Answering the unknown questions about the ability of polyphenols and other bioactives to prevent chronic disease will help substantiate dietary advice. Diet intervention can be safe, low-cost, and implemented over a broad population. It may also be more attractive to consumers than drugs. Confronting these problems now is timely because of the rapidly expanding elderly population, and the high cost of chronic disease to healthy living and health care. Our approach is organized to translate fundamental nutrition research to practical implementation. It is flexible enough to be adapted to different bioactive agents, research questions, and health outcomes.

Publications

  • Andarwulan, N., Kurniasih, D., Apriady, R., Rahmat, H., Roto, A., and Bolling, B. Polyphenols, carotenoids, and ascorbic acid in underutilized medicinal vegetables. Journal of Functional Foods, (2012), 4, 339-347.
  • Bolling, B., Chen, Y-Y., Kamil, A., Chen, C-Y. Assay dilution factors confound measures of total antioxidant capacity in polyphenol-rich juices. Journal of Food Science (2012), 77, H69-H75.
  • Bolling, B., Chen, O., McKay, D., Blumberg, J. Tree Nut Phytochemicals: Composition, Antioxidant Capacity, Bioactivity, Impact Factors. A Systematic Review of Almonds, Brazils, Cashews, Hazelnuts, Macadamias, Pecans, Pine Nuts, Pistachios, and Walnuts. Nutrition Research Reviews (2011), 24, 244-275.
  • Bolling, B., Court, M. H., Blumberg, J., Chen, C-Y. Oliver. Microsomal quercetin glucuronidation in rat small intestine depends on age and segment. Drug Metabolism and Disposition (2011), 39:1406-1014.
  • Bolling, B., Ji, L., Parkin, K. Dietary supplementation of ferulic acid and ferulic acid ethyl ester induces quinone reductase and glutathione-S-transferase in rats. Food Chemistry (2011),124(1), 1-6.
  • Bolling, B., McKay, D, Blumberg, J. The phytochemical composition and antioxidant actions of tree nuts. Asia Pac J Clin Nutr.(2010), 19(1), 117-123.
  • Bolling, B., Blumberg, J., Chen, C-Y. Oliver. The influence of roasting, pasteurization, and storage on the polyphenol content and antioxidant capacity of California almond skins. Food Chemistry (2010), 123(4), 1040-1047.
  • Bolling, B., Dolnikowski, G., Blumberg, J., Chen, C-Y. Oliver. Polyphenol content and antioxidant activity of California almonds depend on cultivar and harvest year. Food Chemistry (2010), 122(3), 819-825.
  • Andarwulan, N., Batari, R. Sandrasari, D. A., Bolling, B., Wijaya, H. Flavonoid content and antioxidant activity of vegetables from Indonesia.  Food Chemistry (2010), 121(4), 1231-1235.
  • Bolling, B., Court, M. H., Blumberg, J., Chen, C-Y. Oliver. The kinetic basis for age-associated changes in quercetin and genistein glucuronidation by rat liver microsomes, Journal of Nutritional Biochemistry (2010), 21(6), 498-503.  
  • Bolling, B., Chen, C-Y., Blumberg, J.  Tea and health: Preventive and therapeutic usefulness in the elderly? Current Opinion in Clinical Nutrition and Metabolic Care (2009), 12, 42-48
  • Bolling, B., Dolnikowski, G., Blumberg, J., Chen, C-Y. Oliver. Quantification of almond skin polyphenols by liquid chromatography-mass spectrometry. Journal of Food Science (2009), 74(4), C326-C332.
  • Bolling, B., Blumberg, J., Chen, C-Y. Oliver. Extraction methods determine the antioxidant capacity and induction of quinone reductase by soy products in vitro. Food Chemistry. (2009), 116(1), 351-355.
  • Bolling, B., Parkin, K. Limited contribution of isoflavones to hepatocellular phase II enzyme-inducing activity of soybean (Glycine max) extracts. Food Chemistry (2009), 113, 1069-1075.
  • Bolling, B., Parkin, K. Phenolic derivatives from soy flour ethanol extract are potent in vitro quinone reductase (QR) inducing agents. Journal of Agricultural and Food Chemistry (2008), 56, 10473-10480.
  • Bolling, B., Chen, E., Parkin, K.  Quinone reductase inducing and antioxidant activities of aqueous isolates of green bean (Phaseolus vulgaris L.).  Food Research International (2007), 40(1), 182-190.
  • Lee, C-H, Wettasinghe, M, Bolling, B., Ji, L., Parkin, K.  Betalains, phase II enzyme-inducing components from red beetroot (Beta vulgaris L.) extracts. Nutrition and Cancer (2005), 53(1), 91-103.
  • Wettasinghe, M., Bolling, B., Plhak, L., Xiao, H., Parkin, K.  Phase II enzyme-inducing and antioxidant activities of beetroot (Beta vulgaris L.) extracts from phenotypes of different pigmentation. Journal of Agricultural and Food Chemistry (2002), 50(23), 6704-6709.
  • Wettasinghe, M., Bolling, B., Plhak, L., Parkin, K.  Screening for phase II enzyme-inducing and antioxidant activities of common vegetables. Journal of Food Science (2002), 67(7), 2583-2588.
  • Ingham, S.C., Bolling, B., Schmidt, D.J.  Development of a simple method for detecting presumptive Escherichia coli on fresh retail beef. Journal of Food Science (2002), 67(1) 258-261.

Recent Presentations

Oral

  • Kim, B., Park, Y., Taheri, R., Kimball, K., Roto, A., Lee, J., and Bolling, B. Polyphenol-rich Aronia melanocarpa (chokeberry) extract regulates expression of cholesterol and lipid metabolism genes in Caco-2 cells. The FASEB Journa (2012). 26, 251.252. Experimental Biology, San Diego CA, April 21-25, 2012.
  • Bolling, B., Court, M., Blumberg, J., Chen, C-Y. Age-related changes in quercetin glucuronidation by rat intestine microsomes are correlated with UGT1a1 protein expression. The FASEB Journal (2011). 25, 234.6 Experimental Biology, Washington DC, April 9-13, 2011.
  • Bolling, B. The influence of cultivar, harvest year, roasting, pasteurization, and storage conditions on polyphenol content and antioxidant capacity of California almond skins. American Chemical Society 241st Annual Meeting, Anaheim CA, March 29-31st, 2011.
  • Bolling, B., Blumberg, J. B., Chen, C.-Y. O The influence of cultivar, harvest year, roasting, pasteurization, and storage conditions on polyphenol content and antioxidant capacity of California almond skins. International Society for Nutraceuticals and Functional Foods Annual Conference. Bali, Indonesia, Oct 11-15, 2010.
  • Bolling, B. Backwards course design & gaining IRB approval for educational research: lessons from Food Fights 101. 2010 IRACDA Conference. Boston, MA.
  • Bolling, B.,   Blumberg, J. B., Chen, C.-Y. O.Contribution of polyphenols to the total antioxidant capacity of pomegranate and grape juices. FASEB J (2010). 24, 321.2. Experimental Biology, Anaheim, CA, April 24-28, 2010.

 

Poster

  • Bolling B, Roto A, Kimball K, Xie L. Extractable and non-extractable proanthocyanidins of nonpareil, carmel, and butte california almonds. The FASEB Journal. (2012) 26:1025.6. Experimental Biology, San Diego CA, April 21-25, 2012.
  • Kim, B., Ku, C. S., Pham, T., Park, Y., Martin, D., Xie, L., Taheri, R., Lee, J., and Bolling, B. Aronia melanocarpa (chokeberry) polyphenol rich extract reduces plasma cholesterol and improves antioxidant function in Apolipoprotien E knockout mice. The FASEB Journal. (2012). 26, 1026.1029. Experimental Biology, San Diego CA, April 21-25, 2012.
  • Blumberg, J., Chen, C.-Y. O., McKay, D., Bolling, B. Nutrient Databank values for the polyphenols and related phytochemicals of tree nuts. 5th International Conference on Polyphenols and Health. Barcelona, Spain, Oct 17-20, 2011.
  • Bolling, B., Chen, C.-Y. O., McKay, D., Blumberg, J. Nutrient Databank values for the phytochemical and antioxidant content of tree nuts. 35th National Nutrient Databank Conference. Bethesda, MD, Apr. 8, 2011.
  • Bolling, B., Chen, C.-Y. O., Blumberg, J. Tree nuts are a good source of nutrients associated with cognitive performance. ILSI Symposium on Nutrition and Cognition. Kuala Lumpur, Malaysia, Oct. 19-21, 2010.
  • Bolling, B., Blumberg, J., Chen, C.-Y. O. Total antioxidant capacity of grape and pomegranate juices in vitro is dependent upon assay dilution factor. The FASEB Journal. (2010) 24, 921.2. Experimental Biology, Anaheim, CA. April 24-28, 2010.
  • Bolling, B., Blumberg, J., Chen, C.-Y. O. Total antioxidant capacity of grape and pomegranate juices in vitro is dependent upon assay dilution factor. FASEB J. (2010) 24, 921.2. Experimental Biology, Anaheim, CA. April 24-28, 2010.

 
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